Product nameNCKX2 peptide
Purity> 95 % SDS-PAGE.
Our Abpromise guarantee covers the use of ab5896 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat Excanger (Na/Ca-k), catalog ab3507. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
ReconstitutionReconstitute with 0.1 ml of distilled water.
- Na(+)/K(+)/Ca(2+) exchange protein 2
- Na(+)/K(+)/Ca(2+)-exchange protein 2
- NCKX 2
FunctionCritical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
Sequence similaritiesBelongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.
- Information by UniProt
ab5896 has not yet been referenced specifically in any publications.