Anti-NDE1 antibody (ab127032)
Key features and details
- Rabbit polyclonal to NDE1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NDE1 antibody
See all NDE1 primary antibodies -
Description
Rabbit polyclonal to NDE1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Chicken, Cow -
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 1 and 163 of Human NDE1.
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Positive control
- IMR32 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab127032 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 38 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 38 kDa. |
Target
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Function
Required for centrosome duplication. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex (By similarity). Required for formation and function of the mitotic spindle. -
Sequence similarities
Belongs to the nudE family. -
Post-translational
modificationsPhosphorylated in mitosis. -
Cellular localization
Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Cleavage furrow. Localizes to the interphase centrosome and to the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. - Information by UniProt
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Database links
- Entrez Gene: 54820 Human
- Entrez Gene: 67203 Mouse
- Entrez Gene: 83836 Rat
- Omim: 609449 Human
- SwissProt: Q9NXR1 Human
- SwissProt: Q9CZA6 Mouse
- SwissProt: Q9ES39 Rat
- Unigene: 655378 Human
see all -
Alternative names
- FLJ20101 antibody
- HOM TES 87 antibody
- LIS1 interacting protein NUDE1 rat homolog antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab127032 has not yet been referenced specifically in any publications.