Overview

  • Product name

    NDSB-201, Zwitterionic non-detergent sulfobetaine
  • Description

    Zwitterionic non-detergent sulfobetaine
  • Biological description

    Zwitterionic non-detergent sulfobetaine. Used to extract, solubilise and crystallise proteins. Prevents protein aggregation and promotes renaturation of denatured proteins.
  • Purity

    > 98%
  • CAS Number

    15471-17-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(Pyridinium-1-yl)propane-1-sulfonate
  • Molecular weight

    201.24
  • Molecular formula

    C8H11NO3S
  • PubChem identifier

    84929
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=[N+](C=C1)CCCS(=O)(=O)[O-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Leibly DJ  et al. Stabilizing additives added during cell lysis aid in the solubilization of recombinant proteins. PLoS One 7:e52482 (2012). Read more (PubMed: 23285060) »
  • da Silva AJ  et al. Purification, crystallization and preliminary crystallographic studies of SPCI-chymotrypsin complex at 2.8 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun 64:914-7 (2008). Read more (PubMed: 18931434) »
  • Willis MS  et al. Investigation of protein refolding using a fractional factorial screen: a study of reagent effects and interactions. Protein Sci 14:1818-26 (2005). Read more (PubMed: 15937284) »

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