NDSB-211, Zwitterionic non-detergent sulfobetaine (ab142231)

Overview

  • Product name

    NDSB-211, Zwitterionic non-detergent sulfobetaine
  • Description

    Zwitterionic non-detergent sulfobetaine
  • Biological description

    Zwitterionic non-detergent sulfobetaine. Used to extract, solubilise and crystallise proteins. Prevents protein aggregation and promotes renaturation of denatured proteins.
  • Purity

    > 98%
  • CAS Number

    38880-58-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[2-Hydroxyethyl(dimethyl)azaniumyl]propane-1-sulfonate
  • Molecular weight

    211.28
  • Molecular formula

    C7H17NO4S
  • PubChem identifier

    4985784
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+](C)(CCCS(=O)(=O)[O-])CCO
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ryan TM  et al. Small amphipathic molecules modulate secondary structure and amyloid fibril-forming kinetics of Alzheimer disease peptide Aß(1-42). J Biol Chem 287:16947-54 (2012). Read more (PubMed: 22461629) »
  • McPherson A & Cudney B Searching for silver bullets: an alternative strategy for crystallizing macromolecules. J Struct Biol 156:387-406 (2006). Read more (PubMed: 17101277) »
  • Vuillard L  et al. Halophilic protein stabilization by the mild solubilizing agents nondetergent sulfobetaines. Anal Biochem 230:290-4 (1995). Read more (PubMed: 7503420) »

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