Overview

  • Product name

    NDSB-221, Zwitterionic non-detergent sulfobetaine
  • Description

    Zwitterionic non-detergent sulfobetaine.
  • Biological description

    Zwitterionic non-detergent sulfobetaine. Used to extract, solubilise and crystallise proteins. Prevents protein aggregation and promotes renaturation of denatured proteins.
  • Purity

    > 97%
  • CAS Number

    160788-56-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(1-Methylpiperidinium-1-yl)propane-1-sulfonate
  • Molecular weight

    221.32
  • Molecular formula

    C9H19NO3S
  • PubChem identifier

    10130697
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[N+]1(CCCCC1)CCCS(=O)(=O)[O-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kubiak X  et al. Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3]. Acta Crystallogr Sect F Struct Biol Cryst Commun 68:196-8 (2012). Read more (PubMed: 22297998) »
  • Backer MV  et al. Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Mol Cancer Ther 4:1423-9 (2005). Read more (PubMed: 16170035) »
  • Vuillard L  et al. Enhancing protein solubilization with nondetergent sulfobetaines. Electrophoresis 16:295-7 (1995). Read more (PubMed: 7607159) »

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