Overview

  • Product name

  • Description

    Rabbit polyclonal to NDST2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 755-815 of Human NDST2 (P52849).

  • Positive control

    • Human stomach (lower) tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab151141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Target

  • Function

    Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate.
  • Pathway

    Glycan metabolism; heparan sulfate biosynthesis.
    Glycan metabolism; heparin biosynthesis.
  • Sequence similarities

    Belongs to the sulfotransferase 1 family. NDST subfamily.
  • Cellular localization

    Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • [Heparan sulfate]-glucosamine N-sulfotransferase antibody
    • bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 antibody
    • Glucosaminyl N-deacetylase/N-sulfotransferase 2 antibody
    • glucosaminyl N-deacetylase/N-sulphotransferase 2 antibody
    • heparan glucosaminyl N-deacetylase/N-sulfotransferase 2 antibody
    • heparan N-sulfotransferase 2 antibody
    • heparan sulfate N-deacetylase/N-sulfotransferase 2 antibody
    • Heparan sulfate N-sulfotransferase 2 antibody
    • HSST2 antibody
    • mastocytoma N-deacetylase/N-sulfotransferase antibody
    • Mndns antibody
    • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 antibody
    • N-heparan sulfate sulfotransferase 2 antibody
    • N-HSST 2 antibody
    • NDST-2 antibody
    • NDST2 antibody
    • NDST2_HUMAN antibody
    • NST2 antibody
    see all

Images

  • Immunocytochemistry/immunofluorescence analysis of PC-3 cells labelling NDST2 with ab151141 shows positive staining in the cytoplasm.
  • Immunohistochemical analysis of paraffin-embedded Human stomach (lower) tissue labeling NDST2 with ab151141 at 1/50 dilution.

References

This product has been referenced in:

  • Kero D  et al. Syndecans and Enzymes Involved in Heparan Sulfate Biosynthesis and Degradation Are Differentially Expressed During Human Odontogenesis. Front Physiol 9:732 (2018). IHC-P ; Human . Read more (PubMed: 29962964) »
See 1 Publication for this product

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