Overview

  • Product name

  • Description

    Rabbit polyclonal to NDUFA1
  • Host species

    Rabbit
  • Specificity

    No cross reactivity with other proteins.
  • Tested applications

    Suitable for: WB, IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to a sequence at the C terminal of Human NDUFA1, different from the related rat and mouse sequences by one amino acid.

  • Positive control

    • Rat Heart, Brain, Liver and Kidney tissue lysates; HT1080 cell lysate; Rat Cardiac Muscle tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab131423 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 8 kDa.
IHC-P Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC Use a concentration of 0.5 - 1 µg/ml.

Target

  • Function

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
  • Tissue specificity

    Primarily expressed in heart and skeletal muscle.
  • Involvement in disease

    Defects in NDUFA1 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
  • Sequence similarities

    Belongs to the complex I NDUFA1 subunit family.
  • Cellular localization

    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CI MWFE antibody
    • CI-MWFE antibody
    • Complex I MWFE antibody
    • complex I MWFE subunit antibody
    • Complex I-MWFE antibody
    • MWFE antibody
    • MWFE, B. taurus, homolog of antibody
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 7.5kDa antibody
    • NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 antibody
    • NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 antibody
    • NADH oxidoreductase subunit MWFE antibody
    • NADH ubiquinone oxidoreductase (complex 1) antibody
    • NADH ubiquinone oxidoreductase MWFE subunit antibody
    • NADH-ubiquinone oxidoreductase 1 alpha subcomplex, 1 antibody
    • NADH-ubiquinone oxidoreductase MWFE subunit antibody
    • NDUA1_HUMAN antibody
    • NDUFA 1 antibody
    • NDUFA1 antibody
    • Type I dehydrogenase antibody
    • ZNF 183 antibody
    • ZNF183 antibody
    see all

Images

  • All lanes : Anti-NDUFA1 antibody (ab131423) at 0.5 µg/ml

    Lane 1 : Rat Heart tissue lysate
    Lane 2 : Rat Brain tissue lysate
    Lane 3 : Rat Liver tissue lysate
    Lane 4 : Rat Kidney tissue lysate
    Lane 5 : HT1080 Cell Lysate

    Predicted band size: 8 kDa

  • Immunohistochemical analysis of paraffin-embedded Rat Cardiac Muscle Tissue labelling NDUFA1 with ab131423 at 1µg/ml.

References

ab131423 has not yet been referenced specifically in any publications.

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