Key features and details
- Rabbit polyclonal to Nebulin
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Nebulin antibody
See all Nebulin primary antibodies
DescriptionRabbit polyclonal to Nebulin
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Nebulin (internal sequence). NP_001157979.
Database link: P20929-2
- Human lung cancer tissue.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
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Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab199259 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200.|
FunctionThis giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Bind and stabilize F-actin.
Tissue specificityMuscle specific. Located in the thin filament of striated muscle.
Involvement in diseaseDefects in NEB are the cause of nemaline myopathy type 2 (NEM2) [MIM:256030]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination.
Sequence similaritiesContains 178 nebulin repeats.
Contains 1 SH3 domain.
Cellular localizationCytoplasm > myofibril > sarcomere. Cytoplasm > cytoskeleton.
- Information by UniProt
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ab199259 has not yet been referenced specifically in any publications.