Anti-NECL-1 antibody (ab215993)
Key features and details
- Rabbit polyclonal to NECL-1
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-NECL-1 antibody
See all NECL-1 primary antibodies -
Description
Rabbit polyclonal to NECL-1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Human -
Immunogen
Synthetic peptide within Human NECL-1 aa 100-200 conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q8N126 -
Positive control
- Mouse brain lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X
Aqueous buffered solution -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab215993 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/100 - 1/1000. Predicted molecular weight: 43 kDa.
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Notes |
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WB
1/100 - 1/1000. Predicted molecular weight: 43 kDa. |
Target
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Function
Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. -
Tissue specificity
Isoform 1 is expressed mainly in adult and fetal brain. Isoform 2 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. -
Sequence similarities
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Domain
The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK. -
Cellular localization
Cell junction. Cell membrane. Localized at the cell-cell attached sites of the plasma membrane. - Information by UniProt
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Database links
- Entrez Gene: 57863 Human
- Entrez Gene: 94332 Mouse
- Entrez Gene: 360882 Rat
- Omim: 609743 Human
- SwissProt: Q8N126 Human
- SwissProt: Q99N28 Mouse
- SwissProt: Q1WIM3 Rat
- Unigene: 365689 Human
see all -
Alternative names
- BIgR antibody
- Brain immunoglobulin receptor antibody
- CADM 3 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab215993 has not yet been referenced specifically in any publications.