Overview

  • Product name
    Necrostatin-1, necroptosis inhibitor
  • Description
    Potent, specific necroptosis inhibitor
  • Biological description
    Potent, specific necroptosis inhibitor (EC50 = 490 nM). Selective allosteric inhibitor of death domain receptor-associated adaptor kinase RIP1 in vitro (EC50 = 182 nM). Caspase independent, programmed necrosis pathway.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Wang YQ  et al. Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 37:1849-58 (2012). Read more (PubMed: 22736198) »
  • Dong K  et al. Necrostatin-1 protects photoreceptors from cell death and improves functional outcome after experimental retinal detachment. Am J Pathol 181:1634-41 (2012). Read more (PubMed: 22940440) »
  • Degterev A  et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1:112-9 (2005). Read more (PubMed: 16408008) »
See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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