Necrostatin-1, necroptosis inhibitor (ab141053)
- Datasheet
- References (4)
Overview
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Product nameNecrostatin-1, necroptosis inhibitor
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DescriptionPotent, specific necroptosis inhibitor
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Biological descriptionPotent, specific necroptosis inhibitor (EC50 = 490 nM). Selective allosteric inhibitor of death domain receptor-associated adaptor kinase RIP1 in vitro (EC50 = 182 nM). Caspase independent, programmed necrosis pathway.
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Purity> 99%
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CAS Number4311-88-0
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Chemical structure
Properties
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Chemical name5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
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Molecular weight259.33
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Molecular formulaC13H13N3OS
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PubChem identifier2828334
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Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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Solubility overviewSoluble in ethanol to 50 mM and in DMSO to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESS=C3NC(Cc1cnc2ccccc12)C(=O)N3C
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Source
Synthetic
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Research areas
Images
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Functional Studies - Necrostatin-1, necroptosis inhibitor (ab141053)Yan et al PLoS One. 2018 Nov 21;13(11):e0207760. doi: 10.1371/journal.pone.0207760. eCollection 2018. Fig 2.Necroptosis exists in PDLSCs.
TEM, a representative normal cell (the cell had a long fusiform, cell membrane structure was complete, the nucleus was round, nucleolus was obvious and center), b representative necroptosis cell (cell membrane ruptured, organelle disappeared, chromatin consolidated and agglutinated, presenting necrotic ultrastructural characteristics), c representative necrosis cell after Nec-1 inhibited (the cell membrane was intact, and the chromatin structure returned to normal).
References
This product has been referenced in:
- Wang YQ et al. Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 37:1849-58 (2012). Read more (PubMed: 22736198) »
- Dong K et al. Necrostatin-1 protects photoreceptors from cell death and improves functional outcome after experimental retinal detachment. Am J Pathol 181:1634-41 (2012). Read more (PubMed: 22940440) »
- Degterev A et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1:112-9 (2005). Read more (PubMed: 16408008) »
