Overview

  • Product name

    Necrostatin-5, Necroptosis inhibitor
  • Description

    Necroptosis inhibitor
  • Biological description

    Inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase.
  • Purity

    > 98%
  • CAS Number

    337349-54-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[[3-(4-Methoxyphenyl)-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]sulfanyl]acetonitrile
  • Molecular weight

    383.49
  • Molecular formula

    C19H17N3O2S2
  • PubChem identifier

    1913406
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Degterev A  et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4:313-21 (2008). Read more (PubMed: 18408713) »
  • Wang K  et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett 17:1455-65 (2007). Read more (PubMed: 17270434) »

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