Overview

  • Product name

    Necrosulfonamide, necroptosis inhibitor
  • Description

    Potent, selective necroptosis inhibitor. MLKL blocker.
  • Biological description

    Potent, selective necroptosis inhibitor (IC50 = 0.2 μM). MLKL blocker. Selectively blocks necrosis downstream of RIP3 activation. Shows selective antinecrotic effects.
  • Purity

    > 98%
  • CAS Number

    432531-71-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
  • Molecular weight

    461.47
  • Molecular formula

    C18H15N5O6S2
  • PubChem identifier

    1566236
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Steinhart L  et al. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis. Cell Death Dis 4:e802 (2013). Read more (PubMed: 24030154) »
  • Sun L  et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148:213-27 (2012). Read more (PubMed: 22265413) »
  • Dunai ZA  et al. Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells. PLoS One 7:e41945 (2012). Read more (PubMed: 22860037) »
See 1 Publication for this product

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