Nedaplatin, derivative of cisplatin and DNA damage agent (ab142046)

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Overview

  • Product name

    Nedaplatin, derivative of cisplatin and DNA damage agent

  • Description

    Platinum compound. Derivative of cisplatin

  • Biological description

    Platinum compound. Derivative of cisplatin (ab141398). Displays antineoplastic and antitumor effects in vitro.

  • Purity

    > 99%

  • CAS Number

    95734-82-0

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    cis-Diammine(glycolato)platinum (II)

  • Molecular weight

    303.18

  • Molecular formula

    C2H8N2O3Pt

  • PubChem identifier

    72120

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(C(=O)O)O.[NH2-].[NH2-].[Pt+2]

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Uehara T  et al. Time course of the change and amelioration of nedaplatin-induced nephrotoxicity in rats. J Appl Toxicol 28:388-98 (2008). Read more (PubMed: 17685399) »
  • Hanada K  et al. Use of a toxicity factor to explain differences in nephrotoxicity and myelosuppression among the platinum antitumour derivatives cisplatin, carboplatin and nedaplatin in rats. J Pharm Pharmacol 60:317-22 (2008). Read more (PubMed: 18284811) »
  • Uchida N  et al. Antitumor efficacy of nedaplatin, a novel platinum complex, with cyclophosphamide in murine and human tumor model. Anticancer Res 18:3375-9 (0). Read more (PubMed: 9858911) »

Publishing research using ab142046? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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