Key features and details
- Goat polyclonal to NEIL1
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-NEIL1 antibody
See all NEIL1 primary antibodies
DescriptionGoat polyclonal to NEIL1
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
- Recombinant Human NEIL1 protein (ab123204) can be used as a positive control in WB.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.05% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab14753 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at a concentration of 5 µg/ml.
Western Blot: preliminary experiments give ~60kDa band in human liver and brain lysates at 1ug/ml. However predicted band size = 44kDa (NP_078884)
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionInvolved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
Sequence similaritiesBelongs to the FPG family.
- Information by UniProt
- DNA (apurinic or apyrimidinic site) lyase Neil1 antibody
- DNA glycosylase/AP lyase Neil 1 antibody
- DNA glycosylase/AP lyase Neil1 antibody
ab14753 has not yet been referenced specifically in any publications.