• Product name

  • Description

    Rabbit polyclonal to NEIL3
  • Host species

  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human NEIL3 aa 491-540. The exact sequence is proprietary.
    Database link: Q8TAT5

  • Positive control

    • IHC-P: Human colon tissue. WB: COLO, HUVEC, HepG2, and HeLa cell extracts.


  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.87% Sodium chloride, 50% Glycerol

    (PBS without Mg2+ and Ca2+).
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab230908 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50.
WB 1/500 - 1/1000. Predicted molecular weight: 68 kDa.


  • Function

    Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected.
  • Tissue specificity

    Detected in thymus and testis. Expressed at higher levels in tumor tissue than in the corresponding normal tissues except for pancreas and testis where expression is higher in normal than tumor tissue.
  • Sequence similarities

    Belongs to the FPG family.
    Contains 1 FPG-type zinc finger.
    Contains 1 RanBP2-type zinc finger.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • 123 antibody
    • AI449477 antibody
    • BC034753 antibody
    • C85903 antibody
    • DNA glycosylase FPG2 antibody
    • DNA glycosylase hFPG2 antibody
    • DNA glycosylase/AP lyase Neil3 antibody
    • EC 3.2.2.- antibody
    • EC antibody
    • Endonuclease 8-like 3 antibody
    • Endonuclease VIII-like 3 antibody
    • FGP2 antibody
    • FLJ10858 antibody
    • FPG2 antibody
    • hFPG2 antibody
    • hNEI3 antibody
    • MGC27861 antibody
    • MGC36916 antibody
    • Nei endonuclease VIII-like 3 (E. coli) antibody
    • nei endonuclease VIII-like 3 antibody
    • Nei like 3 (E. coli) antibody
    • Nei-like protein 3 antibody
    • NEI3 antibody
    • NEIL3 antibody
    • NEIL3_HUMAN antibody
    • OTTHUMP00000218810 antibody
    • RGD1310562 antibody
    see all


  • All lanes : Anti-NEIL3 antibody (ab230908) at 1/500 dilution

    Lane 1 : COLO cell extract
    Lane 2 : HUVEC (human umbilical vein endothelial cell line) cell extract
    Lane 3 : HepG2 (human liver hepatocellular carcinoma cell line) cell extract
    Lane 4 : HeLa (human epithelial cell line from cervix adenocarcinoma) cell extract
    Lane 5 : HUVEC (human umbilical vein endothelial cell line) cell extract with immunizing peptide

    Predicted band size: 68 kDa

  • Formalin-fixed, paraffin-embedded human colon tissue stained for NEIL3 using ab230908 at 1/50 dilution in immunohistochemical analysis.


ab230908 has not yet been referenced specifically in any publications.

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