Overview

  • Product name

    Neomycin sulfate, aminoglycoside antibiotic
  • Description

    Aminoglycoside antibiotic
  • Biological description

    Aminoglycoside antibiotic. Shows bactericidal effects against Gram-negative bacteria in vivo. Partially active against Gram-positive bacteria. Calcium channel protein inhibitor. Orally active.
  • CAS Number

    1405-10-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3S,4R,5R)-5-Amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol sulfate
  • Molecular weight

    712.72
  • Molecular formula

    C23H46N6O13.H2SO4
  • PubChem identifier

    5702091
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [C@@H]1([C@@H]([C@H]([C@H](O[C@H]1CN)O[C@@H]2[C@H](C[C@H]([C@@H]([C@@H]2OC3O[C@@H]([C@H]([C@@H]3O)O[C@H]4O[C@H]([C@H]([C@@H]([C@@H]4N)O)O)CN)CO)O)N)N)N)O)O.S(=O)(=O)(O)O
  • Source

    Streptomyces fradiae

  • Research areas

References

This product has been referenced in:

  • Sugumar S  et al. Ultrasonic emulsification of eucalyptus oil nanoemulsion: antibacterial activity against Staphylococcus aureus and wound healing activity in Wistar rats. Ultrason Sonochem 21:1044-9 (2014). Read more (PubMed: 24262758) »
  • Bushman JD  et al. A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating. PLoS One 8:e63733 (2013). Read more (PubMed: 23700433) »
  • Lin LY  et al. Extracellular Ca(2+) and Mg(2+) modulate aminoglycoside blockade of mechanotransducer channel-mediated Ca(2+) entry in zebrafish hair cells: an in vivo study with the SIET. Am J Physiol Cell Physiol 305:C1060-8 (2013). Read more (PubMed: 24005042) »

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