Overview

  • Product name

    Neosolaniol, trichothecene mycotoxin
  • Description

    Potent trichothecene mycotoxin
  • Biological description

    Potent trichothecene mycotoxin. Inhibits protein synthesis. Induces DNA fragmentation and apoptosis. Depletes lymphoid and hematopoietic tissues in vivo. Orally active. Skin permeable.
  • Purity

    > 98%
  • CAS Number

    36519-25-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4β,15-Diazetoxy-3α,8α-dihydroxy-12,13-epoxytrichothec-9-ene
  • Molecular weight

    382.40
  • Molecular formula

    C19H26O8
  • PubChem identifier

    5458421
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC2[C@](C[C@@H]1O)([C@]3([C@@H]([C@H]([C@H]([C@]34CO4)O2)O)OC(=O)C)C)COC(=O)C
  • Source

    Fusarium sp.

  • Research areas

References

This product has been referenced in:

  • Islam Z  et al. Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice. Biosci Biotechnol Biochem 62:1492-7 (1998). Read more (PubMed: 9757554) »
  • Anderson DW  et al. Structure-activity studies of trichothecenes: cytotoxicity of analogues and reaction products derived from T-2 toxin and neosolaniol. J Med Chem 32:555-62 (1989). Read more (PubMed: 2918501) »
  • Hoerr FJ  et al. Experimental trichothecene mycotoxicosis produced in broiler chickens by Fusarium sporotrichiella var. sporotrichioides. Avian Pathol 11:385-405 (1982). Read more (PubMed: 18770204) »

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