Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.
Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.
Belongs to the nephronectin family. Contains 5 EGF-like domains. Contains 1 MAM domain.
Expressed in fetal kidney, cochlea, eye, heart and lung.
The MAM domain is required for localization at the cell surface.
Secreted > extracellular space > extracellular matrix. Trapped on the cell surface or in the extracellular matrix.