Nepsilon-(1-Carboxyethyl)-L-lysine (mixture of diastereoisomers) (ab145095)

Overview

  • Product name

    Nepsilon-(1-Carboxyethyl)-L-lysine (mixture of diastereoisomers)
  • Description

    Stable, nonenzymatic chemical modification of protein lysine residues.
  • Alternative names

    • CEL
    • N6-(1-Carboxyethyl)-L-lysine
    • N6-(1’-Carboxyethyl)lysine
  • Biological description

    Stable, nonenzymatic chemical modification of protein lysine residues resulting from glycation and oxidation reactions.

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Nε-(1-Carboxyethyl)lysineN6-(1-Carboxyethyl)-L-lysine
  • Molecular weight

    218.25
  • Molecular formula

    C9H18N2O4
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Tareke E  et al. Isotope dilution ESI-LC-MS/MS for quantification of free and total Ne-(1-Carboxymethyl)-L-Lysine and free Ne-(1-Carboxyethyl)-L-Lysine: comparison of total Ne-(1-Carboxymethyl)-L-Lysine levels measured with new method to ELISA assay in gruel samples. Food Chem 141:4253-9 (2013). Read more (PubMed: 23993613) »
  • Ahmed N  et al. Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin. Biochem J 364:1-14 (2002). Read more (PubMed: 11988070) »
  • Ahmed MU  et al. N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochem J 324 ( Pt 2):565-70 (1997). Read more (PubMed: 9182719) »

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