Anti-Netrin 1 antibody (ab122903)

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Overview

  • Product name

    Anti-Netrin 1 antibody
    See all Netrin 1 primary antibodies

  • Description

    Goat polyclonal to Netrin 1

  • Host species

    Goat

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Dog

  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids of Human Netrin 1.

  • Positive control

    • Human Intestine tissue; Rat, Mouse and Human Brain lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab122903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 68 kDa).
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function

    Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

  • Tissue specificity

    Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.

  • Sequence similarities

    Contains 3 laminin EGF-like domains.
    Contains 1 laminin N-terminal domain.
    Contains 1 NTR domain.

  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • epididymis tissue protein Li 131P antibody
    • NET1_HUMAN antibody
    • Netrin 1, mouse, homolog of antibody
    • Netrin 1-like antibody
    • Netrin-1 antibody
    • Netrin1 antibody
    • Ntn 1 antibody
    • NTN 1L antibody
    • NTN1 antibody
    • NTN1L antibody
    • Unc6 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Netrin 1 antibody (ab122903)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Netrin 1 antibody (ab122903)
    ab122903, at 3.75 µg/ml, staining Netrin 1 in Formalin-fixed, Paraffin-embedded Human Intestine tissue by Immunohistochemistry.
  • Western blot - Anti-Netrin 1 antibody (ab122903)
    Western blot - Anti-Netrin 1 antibody (ab122903)
    Anti-Netrin 1 antibody (ab122903) at 0.5 µg/ml + Rat Brain lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 68 kDa

References

This product has been referenced in:

  • Yin K  et al. Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin. J Cancer 10:3197-3207 (2019). Read more (PubMed: 31289590) »
  • Wang J  et al. Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats. Front Cell Neurosci 11:432 (2017). Read more (PubMed: 29375318) »
See all 3 Publications for this product

Publishing research using ab122903? Please let us know so that we can cite the reference in this datasheet.

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