Product nameAnti-Netrin 1 antibody
See all Netrin 1 primary antibodies
DescriptionChicken polyclonal to Netrin 1
Tested applicationsSuitable for: IHC-P, IHC-Fr, ICC/IF, WBmore details
Species reactivityReacts with: Mouse, Human
Synthetic peptide corresponding to a region of the Netrin 1 gene product shared between the mouse (O09118, NCBI) and human (O95631, NCBI) gene products.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.02% Sodium Azide
Constituents: PBS (10mM isotonic 0.9% w/v), pH 7.2
Concentration information loading...
Purification notesAfter repeated injections into the hens, immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity-purified using a peptide column, the concentrations of the eluate adjusted to 100 ug/ml, and the preparation filter-sterilized.
Our Abpromise guarantee covers the use of ab39370 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/200.|
|IHC-Fr||1/100 - 1/200.|
|ICC/IF||1/100 - 1/200.|
|WB||1/250 - 1/500. Predicted molecular weight: 68 kDa.|
FunctionNetrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Tissue specificityWidely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.
Sequence similaritiesContains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.
Contains 1 NTR domain.
Cellular localizationSecreted > extracellular space > extracellular matrix.
- Information by UniProt
- epididymis tissue protein Li 131P antibody
- NET1_HUMAN antibody
- Netrin 1, mouse, homolog of antibody
This product has been referenced in:
- Cayre M et al. Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination. Development 140:3107-17 (2013). Read more (PubMed: 23824572) »
- Chen Q et al. N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors. J Cell Sci 126:186-95 (2013). Read more (PubMed: 23038776) »