Product nameNetropsin dihydrochloride, DNA minor groove binding ligand
DescriptionDNA minor groove binding ligand.
DNA minor groove binding ligand with potential antibiotic and antiviral properties. Binds to AT-rich regions in dsDNA, and has the ability to block DNA helicase, Topoisomerase and endonuclease, and also to interfere with transcription factor binding in these regions. Binds to dsDNA in a non-intercalative manner.
Chemical nameN-[4-[(3-Amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(diaminomethylideneamino)acetyl]amino]-1-methylpyrrole-2-carboxamide dihydrochloride
Storage instructionsStore at -20°C (desiccating conditions).
Solubility overviewSoluble in water (1 mg/mL)
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This product has been referenced in:
- Premvardhan L & Maurizot JC Netropsin binding in five duplex-dimer DNA constructs as a function of size and distance between binding sites: circular dichroism and absorption spectroscopy. Eur Biophys J 39:781-7 (2010). Read more (PubMed: 19859703) »
- Grant MA et al. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J 418:103-12 (2009). Read more (PubMed: 18937643) »
- Mishra K et al. Netropsin, a minor groove binding ligand: a potential radioprotective agent. Radiat Res 172:698-705 (2009). Read more (PubMed: 19929416) »
- Bielawski K et al. Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2. Acta Biochim Pol 47:855-66 (2000). Read more (PubMed: 11310985) »
- Ren J & Chaires JB Sequence and structural selectivity of nucleic acid binding ligands. Biochemistry 38:16067-75 (1999). Read more (PubMed: 10587429) »
- Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta 1090:52-60 (1991). Read more (PubMed: 1653020) »