Overview

  • Product name

  • Description

    Goat polyclonal to Neurexin 1
  • Host species

    Goat
  • Specificity

    This antibody is expected to recognise both reported isoforms (NP_004792.1 and NP_620072.1).
  • Tested applications

    Suitable for: ELISA, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    A synthetic peptide correspoding to a C terminal end of Neurexin 1 (Human)(NP_004792.1 , NP_620072.1)

  • Positive control

    • Human brain (Cerebellum) lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab79587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA: Use at an assay dependent dilution. Antibody detection limit in peptide ELISA assay: 1/32000.
    WB: Use at a concentration of 0.05 - 0.1 µg/ml. Predicted molecular weight: 162 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.
    • Tissue specificity

      Brain.
    • Sequence similarities

      Belongs to the neurexin family.
      Contains 3 EGF-like domains.
      Contains 6 laminin G-like domains.
    • Post-translational
      modifications

      N-glycosylated.
      O-glycosylated.
    • Cellular localization

      Cell membrane. Cell junction, synapse. Localized on the pre-synaptic membrane.
    • Information by UniProt
    • Database links

    • Form

      The neurexin genes use alternate promoters, splice sites and exons to encode potentially hundreds or thousands of mRNA transcripts.
    • Alternative names

      • DKFZp313P2036 antibody
      • FLJ35941 antibody
      • Hs.22998 antibody
      • KIAA0578 antibody
      • Neurexin 1 alpha antibody
      • Neurexin 1 beta antibody
      • Neurexin I-alpha antibody
      • Neurexin-1 antibody
      • Neurexin-1-alpha antibody
      • NRX1A_HUMAN antibody
      • NRXN1 antibody
      • PTHSL2 antibody
      • SCZD17 antibody
      see all

    Images

    References

    ab79587 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Answer

    I have spoken with the lab regarding ab79587. We have not yet tested this product in ICC. For untested applications, we have established a testing discount program. Here is a brief description of how it works: The testing discount program is for customers who like to use an antibody/protein on an untested species/application. You would purchase the antibody at full price, test it and submit an Abreview with your data (positive or negative). On your next order you will receive a discount equal to the value of the product tested. The terms and conditions of this offer can be found here: https://www.abcam.com/AbTrial I have asked the lab to run alignments of the immunogen for ab79587 to the sequences which you have provided. There is 98.2% homology between the isoforms of mouse Neurexin 1 and the immunogen for this product. There is only 42% homology with Nrxn2-008, we do not expect reactivity with this protein.

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