Product nameAnti-Neuro D4 antibody - C-terminal
See all Neuro D4 primary antibodies
DescriptionRabbit polyclonal to Neuro D4 - C-terminal
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant fragment corresponding to Human Neuro D4 aa 190-387.
RDKPYVCDICGKRYKNRPGLSYHYTHTHLAEEEGEENAERHALPFHRKNN HKQFYKELAWVPEAQRKHTAKKAPDGTVIPNGYCDFCLGGSKKTGCPEDL ISCADCGRSGHPSCLQFTVNMTAAVRTYRWQCIECKSCSLCGTSENDDQL LFCDDCDRGYHMYCLSPPMAEPPEGSWSCHLCLRHLKEKASAYITLT
Database link: BC125153
- U87 cell lysate; Human fetal brain tissue
FormLyophilised:Reconstitute in 200 ul sterile H2O.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab199299 in the following tested applications.
|IHC-P||1/100 - 1/500.|
|WB||1/200 - 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 44 kDa).|
FunctionMay have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Sequence similaritiesBelongs to the requiem/DPF family.
Contains 2 PHD-type zinc fingers.
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
- BAF45B antibody
- BRG1-associated factor 45B antibody
- D4 antibody
ab199299 has not yet been referenced specifically in any publications.