Recombinant
RabMAb

Recombinant Anti-NeuroD1 antibody [EPR4008] - BSA and Azide free (ab239955)

Overview

  • Product name

    Anti-NeuroD1 antibody [EPR4008] - BSA and Azide free
    See all NeuroD1 primary antibodies
  • Description

    Rabbit monoclonal [EPR4008] to NeuroD1 - BSA and Azide free
  • Host species

    Rabbit
  • Tested applications

    Suitable for: EMSA, IP, WBmore details
    Unsuitable for: Flow Cyt,ICC or IHC-P
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human NeuroD1. The exact sequence is proprietary.

  • General notes

    Ab239955 is the carrier-free version of ab109224. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    ab239955 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Maxpar® is a trademark of Fluidigm Canada Inc.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab239955 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
EMSA Use at an assay dependent concentration. PubMed: 23269676
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Detects a band of approximately 47 kDa (predicted molecular weight: 40 kDa).
EMSA Use at an assay dependent concentration. PubMed: 23269676
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IHC-P.
  • Target

    • Function

      Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
    • Involvement in disease

      Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • Sequence similarities

      Contains 1 basic helix-loop-helix (bHLH) domain.
    • Post-translational
      modifications

      Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
    • Cellular localization

      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • atonal antibody
      • basic helix loop helix transcription factor antibody
      • BETA 2 antibody
      • Beta cell E box transactivator 2 antibody
      • BETA2 antibody
      • BHF 1 antibody
      • BHF1 antibody
      • bHLHa3 antibody
      • class A basic helix loop helix protein 3 antibody
      • Class A basic helix-loop-helix protein 3 antibody
      • MODY 6 antibody
      • MODY6 antibody
      • NDF1_HUMAN antibody
      • NeuroD antibody
      • NeuroD1 antibody
      • Neurogenic differentiation 1 antibody
      • Neurogenic differentiation factor 1 antibody
      • neurogenic helix loop helix protein NEUROD antibody
      • Neuronal differentiation 1 antibody
      see all

    References

    ab239955 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab239955.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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