Key features and details
- Rabbit polyclonal to Neurofibrillary tangles
- Suitable for: WB, IHC-P, IHC-Fr, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Neurofibrillary tangles antibody
DescriptionRabbit polyclonal to Neurofibrillary tangles
Tested applicationsSuitable for: WB, IHC-P, IHC-Fr, ELISAmore details
Species reactivityReacts with: Human
Tissue, cells or virus corresponding to Human Neurofibrillary tangles. Neurofibrillary tangles which were extracted in boiling SDS and purified by sucrose gradient centrifugation.
- Human Alzheimer's brain tissue
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
Concentration information loading...
Our Abpromise guarantee covers the use of ab136407 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
RelevanceNeurofibrillary tangles consist of insoluble twisted fibers that are found inside of the brain's cells. They primarily consist of a protein called tau, which forms part of a structure called a microtubule. The microtubule helps transport nutrients and other important substances from one part of the nerve cell to another. In Alzheimer's disease, however, the tau protein is abnormal and the microtubule structures collapse.
- NFT antibody
ab136407 has been referenced in 1 publication.
- Mu JS et al. Rg1 exhibits neuroprotective effects by inhibiting the endoplasmic reticulum stress-mediated c-Jun N-terminal protein kinase apoptotic pathway in a rat model of Alzheimer's disease. Mol Med Rep 12:3862-3868 (2015). PubMed: 26016457