Overview

  • Product name

    Anti-Neurofibrillary tangles antibody
  • Description

    Rabbit polyclonal to Neurofibrillary tangles
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, IHC-Fr, ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human Neurofibrillary tangles. Neurofibrillary tangles which were extracted in boiling SDS and purified by sucrose gradient centrifugation.

  • Positive control

    • Human Alzheimer's brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab136407 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500.
IHC-P 1/200.
IHC-Fr 1/2000.
ELISA 1/4000.

Target

  • Relevance

    Neurofibrillary tangles consist of insoluble twisted fibers that are found inside of the brain's cells. They primarily consist of a protein called tau, which forms part of a structure called a microtubule. The microtubule helps transport nutrients and other important substances from one part of the nerve cell to another. In Alzheimer's disease, however, the tau protein is abnormal and the microtubule structures collapse.
  • Alternative names

    • NFT antibody

Images

  • Immunohistochemical analysis of tangles and senile plaques in Human Alzheimer's brain tissue using ab136407 at a dilution of 1/200.

References

This product has been referenced in:

  • Mu JS  et al. Rg1 exhibits neuroprotective effects by inhibiting the endoplasmic reticulum stress-mediated c-Jun N-terminal protein kinase apoptotic pathway in a rat model of Alzheimer's disease. Mol Med Rep 12:3862-3868 (2015). Read more (PubMed: 26016457) »
See 1 Publication for this product

Customer reviews and Q&As

Question
Answer

Thank you for contacting us.

I have contacted laboratory for WB images however my colleague have mentioned that these antibodies were published in collaboration with other laboratories so the data is not available. The antibody specificity has been tested and is fully guaranteed.

I am sorry we are unable to provide any data, however the offer we discussed yesterday still stands. So contact me for Abtrial code, buy the antibody, test it in WB, submit Abreview with Image, and get a product free of charge from us. In case the product don't work we will refund your money.

More information can be found at the below given link;

https://www.abcam.com/index.html?pageconfig=resource&rid=11998&viapagetrap=collaborationdiscount

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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