Anti-Neuron navigator 1 antibody [KT124] (ab201920)
Key features and details
- Rat monoclonal [KT124] to Neuron navigator 1
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-Neuron navigator 1 antibody [KT124] -
Description
Rat monoclonal [KT124] to Neuron navigator 1 -
Host species
Rat -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant fragment corresponding to Human Neuron navigator 1 aa 700-1050.
Database link: Q8NEY1 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
ab201920 is purified from culture supernatant using a protein G column. -
Clonality
Monoclonal -
Clone number
KT124 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab201920 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration.
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Notes |
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WB
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
Target
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Relevance
The development of the nervous system (NS) requires the coordinated migration of multiple waves of neurons and subsequent processes of neurite maturation, both involving selective guidance mechanisms. In Caenorhabditis elegans, unc-53 codes for a new multidomain protein involved in the directional migration of a subset of cells. We describe here the first functional characterization of the mouse homologue, mouse Neuron navigator 1 (mNAV1) expression is primarily restricted to the CNS during development. mNAV1 is a microtubules associated protein. The abolition of mNAV1 causes loss of directionality in the leading processes of pontine-migrating cells, providing evidence for a role of mNAV1 in mediating (Netrin1-induced) directional migration. -
Cellular localization
Cytoplasm › cytoskeleton. Note: Associates with a subset of microtubule plus ends. Enriched in neuronal growth cone. -
Database links
- Entrez Gene: 89796 Human
- Entrez Gene: 215690 Mouse
- Omim: 611628 Human
- SwissProt: Q8NEY1 Human
- SwissProt: Q8CH77 Mouse
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Alternative names
- DKFZp781D0314 antibody
- FLJ12560 antibody
- FLJ14203 antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (2)
ab201920 has been referenced in 2 publications.
- Mendoza-Topaz C et al. BioID identifies proteins involved in the cell biology of caveolae. PLoS One 13:e0209856 (2018). PubMed: 30589899
- van Haren J et al. Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension. Curr Biol 24:1778-85 (2014). PubMed: 25065758