Key features and details
- Rat monoclonal [KT124] to Neuron navigator 1
- Reacts with: Human
- Isotype: IgG2a
Product nameAnti-Neuron navigator 1 antibody [KT124]
DescriptionRat monoclonal [KT124] to Neuron navigator 1
Species reactivityReacts with: Human
Predicted to work with: Mouse
Recombinant fragment corresponding to Human Neuron navigator 1 aa 742-1008.
KAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKS FVKPPSLANLDKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCF TPSPAPILNINSASFSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMP MSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPRAGQLDSNQRDRN TLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSA KGQLTNIVSPTAATTPR
Database link: Q8NEY1
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein G purified
Purification notesab201920 is purified from culture supernatant using a protein G column.
RelevanceThe development of the nervous system (NS) requires the coordinated migration of multiple waves of neurons and subsequent processes of neurite maturation, both involving selective guidance mechanisms. In Caenorhabditis elegans, unc-53 codes for a new multidomain protein involved in the directional migration of a subset of cells. We describe here the first functional characterization of the mouse homologue, mouse Neuron navigator 1 (mNAV1) expression is primarily restricted to the CNS during development. mNAV1 is a microtubules associated protein. The abolition of mNAV1 causes loss of directionality in the leading processes of pontine-migrating cells, providing evidence for a role of mNAV1 in mediating (Netrin1-induced) directional migration.
Cellular localizationCytoplasm › cytoskeleton. Note: Associates with a subset of microtubule plus ends. Enriched in neuronal growth cone.
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ab201920 has been referenced in 2 publications.
- Mendoza-Topaz C et al. BioID identifies proteins involved in the cell biology of caveolae. PLoS One 13:e0209856 (2018). PubMed: 30589899
- van Haren J et al. Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension. Curr Biol 24:1778-85 (2014). PubMed: 25065758