Anti-Neuropeptide Y antibody [8] (ab112473)
Key features and details
- Mouse monoclonal [8] to Neuropeptide Y
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG1
Overview
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Product name
Anti-Neuropeptide Y antibody [8]
See all Neuropeptide Y primary antibodies -
Description
Mouse monoclonal [8] to Neuropeptide Y -
Host species
Mouse -
Specificity
Cross-reactivity with Neuropeptide Y(1-24), Neuropeptide Y (18-36), Peptide YY or Pancreatic Polypeptide was <0.2%. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Synthetic peptide corresponding to a region within Human/Rat Neuropeptide Y adsorbed onto aluminum hydroxide gel.
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Epitope
The epitope of ab112473 is probably around the mid-molecular region of Neuropeptide Y. -
Positive control
- Mouse brain tissue (fibres in the hilus of the hippocampus, following epiletic attack) Mouse brain tissue (interneurons in the cortex)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituents: 2.9% Sodium chloride, 97% PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
8 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab112473 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (1) |
1/1000.
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Notes |
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IHC-P
1/1000. |
Target
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Function
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. -
Tissue specificity
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. -
Sequence similarities
Belongs to the NPY family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 4852 Human
- Entrez Gene: 109648 Mouse
- Omim: 162640 Human
- SwissProt: P01303 Human
- SwissProt: P57774 Mouse
- Unigene: 1832 Human
- Unigene: 154796 Mouse
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Alternative names
- C-flanking peptide of NPY antibody
- CPON antibody
- Neuropeptide tyrosine antibody
see all
Images
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ab112473, at 1/1000, staining Neuropeptide Y in paraffin embedded Mouse brain tissue (fibres in the hilus of the hippocampus) from a mouse suffering an epiletic attack just before perfusion by Immunohistochemistry.
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ab112473, at 1/1000, staining Neuropeptide Y in paraffin embedded Mouse brain tissue (fibres in the hilus of the hippocampus) from a mouse suffering an epiletic attack just before perfusion by Immunohistochemistry.
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ab112473, at 1/1000, staining Neuropeptide Y in paraffin embedded Mouse brain tissue (interneurons in the cortex) by Immunohistochemistry.
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Immunofluorescence images of tissue from human cerebral cortex, applying ab112473 to ultra thin sections (antibody: green,
DAPI-stained nuclei: blue). The antibody labels NPY-positive processes in the neutrophil.
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Immunofluorescence images of tissue from human cerebral cortex, applying ab112473 to ultra thin sections (antibody: green,
DAPI-stained nuclei: blue). The antibody labels NPY-positive processes in the neutrophil.
Datasheets and documents
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SDS download
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Datasheet download
References (10)
ab112473 has been referenced in 10 publications.
- vonderEmbse AN et al. Developmental exposure to DDT or DDE alters sympathetic innervation of brown adipose in adult female mice. Environ Health 20:37 (2021). PubMed: 33794904
- Yuan S et al. Sympathetic activity is correlated with satellite cell aging and myogenesis via ß2-adrenoceptor. Stem Cell Res Ther 12:505 (2021). PubMed: 34530910
- Kluge N et al. Rapid measurement of cardiac neuropeptide dynamics by capacitive immunoprobe in the porcine heart. Am J Physiol Heart Circ Physiol 320:H66-H76 (2021). PubMed: 33095651
- Hoang JD et al. Cardiac sympathetic activation circumvents high-dose beta blocker therapy in part through release of neuropeptide Y. JCI Insight 5:N/A (2020). PubMed: 32493842
- Abbineni PS et al. Chromogranin A, the major lumenal protein in chromaffin granules, controls fusion pore expansion. J Gen Physiol 151:118-130 (2019). PubMed: 30504267
- Kim JS et al. Neuropeptides Profile and Increased Innervation in Becker's Nevus. Ann Dermatol 31:154-163 (2019). PubMed: 33911564
- Harris KD et al. Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics. PLoS Biol 16:e2006387 (2018). PubMed: 29912866
- Griggs JL et al. Caralluma fimbriata extract activity involves the 5-HT2c receptor in PWS Snord116 deletion mouse model. Brain Behav 8:e01102 (2018). PubMed: 30353709
- Xu X et al. Altered expression of neuropeptide Y, Y1 and Y2 receptors, but not Y5 receptor, within hippocampus and temporal lobe cortex of tremor rats. Neuropeptides 48:97-105 (2014). IHC-P ; Mouse . PubMed: 24444822
- Weiss AN et al. Protein mobility within secretory granules. Biophys J 107:16-25 (2014). PubMed: 24988337