Alzheimer's disease

Explore Alzheimer's disease and access the tools you need to better understand this complex condition.

Alzheimer's disease (AD) is the most common form of dementia, affecting approximately 50 million people worldwide as of 2018 – a number expected to reach 152 million in 2050.¹ The neuropathology of AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles outside and inside neurons respectively. 

Here you can take a deeper look at the disease and its pathophysiology, as well as a better understanding of the antibodies, kits, reagents, and other tools you need for your research. 

Overview

• Alzheimer’s disease pathway​
• The role of biomarkers in Alzheimer's disease
• Beta-amyloid and tau
  • ​​Tau (phospho T217) product highlight
• Key cell and neuronal markers
• Solutions to support Alzheimer's disease research
• References

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Alzheimer's disease pathway

Explore our Alzheimer's disease pathway poster to understand how proteins interact in this complex disease. Click on the purple information symbol to find a wide range of tools to study your target and accelerate your research.

Get the pathway poster.    

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The role of biomarkers in Alzheimer's disease

Learn more about the challenges posed by the blood-brain barrier and the role of biomarkers in AD from Professor Sudha Seshadri, Founding Director of the Glenn Briggs Institute of Alzheimer’s and Neurogenerative Diseases, UT Health San Antonio.

Here Prof. Seshadri highlights the advantages of blood analysis and the importance of biomarkers that can freely cross the blood-brain barrier. Prof. Seshadri talks us through available biomarkers in AD including growth factors (BDNF, NGF, VEGF), markers of microglial inflammation (YKL40), and astrocyte injury (GFAP). She also emphasizes the importance of using classic markers of amyloid and tau. 

​​​​Please find our products to some of the targets mentioned in our interactive pathway poster.

​Find out in this application note how you can achieve fast and accurate detection of Alzheimer’s disease targets with SimpleStep ELISA^® kits and SPECTROstar^®Nano

Beta-amyloid and tau 

Beta-amyloid and tau are two of the biggest players in AD research. To find out more about the role of beta-amyloid and tau in AD progression and to find out more about the products we have available, click the link below.

Tau phosphorylation

Tau function is governed by phosphorylation, which becomes dysregulated during pathology, resulting in mislocalization, aggregation, and neuronal death. Effortlessly study all aspects of tau phosphorylation with recombinant antibodies against different post-translationally modified sites.

Tau (phospho T217) product highlight

	Recombinant Anti-Tau (phospho T217) antibody [EPR24654-24] (ab288160) Rabbit monoclonal to Tau (phospho T217) Suitable for: Dot blot, ELISA Reacts with: Human A carrier-free version of this antibody is also available.

>>Beta-amyloid and tau tools and reagents

The role of astrocytes in Alzheimer's disease​

Learn more about the role of astrocytes in AD from Professor Shane Liddelow, Principal Investigator at the Liddelow lab.
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Solutions to support Alzheimer's disease research

Achieve results faster with high-quality, disease-relevant products.

From recombinant antibodies to high-throughput assays, we provide a wide range of solutions to support your Alzheimer's research and enable you to be ready for the next stage in your discovery pipeline.

Explore the table below to learn more about our premium product ranges.

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References

1. Alzheimer’s Research UK. Dementia Statistics Hub - Global Prevalence. Available at: https://www.dementiastatistics.org/statistics/global-prevalence/.
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