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Alzheimer's disease (AD) is the most common form of dementia, affecting approximately 50 million people worldwide as of 2018 – a number expected to reach 152 million in 2050.1 The neuropathology of AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles outside and inside neurons respectively.
Here you can take a deeper look at the disease and its pathophysiology, as well as a better understanding of the antibodies, kits, reagents, and other tools you need for your research.
Explore our Alzheimer's disease pathway poster to understand how proteins interact in this complex disease. Click on the purple information symbol to find a wide range of tools to study your target and accelerate your research.
Learn more about the challenges posed by the blood-brain barrier and the role of biomarkers in AD from , Founding Director of the Glenn Briggs Institute of Alzheimer’s and Neurogenerative Diseases, UT Health San Antonio.
Here Prof. Seshadri highlights the advantages of blood analysis and the importance of biomarkers that can freely cross the blood-brain barrier. Prof. Seshadri talks us through available biomarkers in AD including growth factors (BDNF, NGF, VEGF), markers of microglial inflammation (YKL40), and astrocyte injury (GFAP). She also emphasizes the importance of using classic markers of amyloid and tau.
Please find our products to some of the targets mentioned in our interactive pathway poster.
Beta-amyloid and tau are two of the biggest players in AD research. To find out more about the role of beta-amyloid and tau in AD progression and to find out more about the products we have available, click the link below.
Tau function is governed by phosphorylation, which becomes dysregulated during pathology, resulting in mislocalization, aggregation, and neuronal death. Effortlessly study all aspects of tau phosphorylation with recombinant antibodies against different post-translationally modified sites.
Rabbit monoclonal to Tau (phospho T217)
Suitable for: Dot blot, ELISA
Reacts with: Human
A carrier-free version of this antibody is also available.
Learn more about the role of astrocytes in AD from
Achieve results faster with high-quality, disease-relevant products.
From recombinant antibodies to high-throughput assays, we provide a wide range of solutions to support your Alzheimer's research and enable you to be ready for the next stage in your discovery pipeline.
Explore the table below to learn more about our premium product ranges.
Achieve superior batch-to-batch consistency and unrivaled specificity with our recombinant antibodies
Carrier-free and primary conjugated antibodies
With an extensive range of labels, enjoy the freedom of creating a workflow that will take you swiftly from start to finish.
Recombinant proteins and peptides
Our class-leading recombinant proteins have an unrivaled specification and are ideal for preclinical cell culture and functional studies.
Biochemicals are powerful tools for probing biological systems. Explore our highly-cited biochemical range to support your program.
Gene-edited cell lines
Save time and advance your discovery workflow with reliable and well-characterized gene-edited cell lines.
Human iPSC-derived cells
Access highly-defined and consistent hiPSCs for research, drug discovery, and high-throughput screening.
Get the most out of your research and high-throughput screening with our ELISA-based tools.