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Alzheimer's disease

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                  • AD primary antibodies
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                            Explore Alzheimer's disease and access the tools you need to better understand this complex condition.

                            Alzheimer's disease (AD) is the most common form of dementia, affecting approximately 50 million people worldwide as of 2018 – a number expected to reach 152 million in 2050.1 The neuropathology of AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles outside and inside neurons respectively. 

                            Here you can take a deeper look at the disease and its pathophysiology, as well as a better understanding of the antibodies, kits, reagents, and other tools you need for your research. 

                            Overview

                            • Alzheimer’s disease pathway​
                            • The role of biomarkers in Alzheimer's disease
                            • Beta-amyloid and tau
                              • ​​Tau (phospho T217) product highlight
                            • Key cell and neuronal markers
                            • Solutions to support Alzheimer's disease research
                            • References

                            ​​

                            Alzheimer's disease pathway

                            Explore our Alzheimer's disease pathway poster to understand how proteins interact in this complex disease. Click on the purple information symbol to find a wide range of tools to study your target and accelerate your research.

                            Get the pathway poster.    

                            ​​

                            ​​​​


                            The role of biomarkers in Alzheimer's disease

                            Learn more about the challenges posed by the blood-brain barrier and the role of biomarkers in AD from Professor Sudha Seshadri, Founding Director of the Glenn Briggs Institute of Alzheimer’s and Neurogenerative Diseases, UT Health San Antonio.

                            Here Prof. Seshadri highlights the advantages of blood analysis and the importance of biomarkers that can freely cross the blood-brain barrier. Prof. Seshadri talks us through available biomarkers in AD including growth factors (BDNF, NGF, VEGF), markers of microglial inflammation (YKL40), and astrocyte injury (GFAP). She also emphasizes the importance of using classic markers of amyloid and tau. 

                            Learn more about the role of astrocytes in AD and other neurogenerative diseases from Assistant Professor Shane Liddelow from the Department of Neuroscience and Physiology at NYU Langone Medical Center. Here Prof. Liddelow covers topics including the role of astrocytes in response to AD, the mechanism of inducing reactive astrocytes, and astrocyte function in chronic neurodegenerative diseases. He also touches on some of his most recent work investigating the role of microglia in the activation of astrocytic response in neurodegeneration2.

                            Watch here to learn more about the role of astrocytes in neurodegenerative disease.

                            ​​​​Please find our products to some of the targets mentioned in our interactive pathway poster.


                            ​Find out in this application note how you can achieve fast and accurate detection of Alzheimer’s disease targets with SimpleStep ELISA® kits and SPECTROstar®Nano



                            Beta-amyloid and tau 

                            Beta-amyloid and tau are two of the biggest players in AD research. To find out more about the role of beta-amyloid and tau in AD progression and to find out more about the products we have available, click the link below.

                            Tau phosphorylation

                            Tau function is governed by phosphorylation, which becomes dysregulated during pathology, resulting in mislocalization, aggregation, and neuronal death. Effortlessly study all aspects of tau phosphorylation with recombinant antibodies against different post-translationally modified sites.

                            Tau (phospho T217) product highlight



                            Recombinant Anti-Tau (phospho T217) antibody [EPR24654-24] (ab288160)

                            Rabbit monoclonal to Tau (phospho T217)

                            Suitable for: Dot blot, ELISA

                            Reacts with: Human

                            A carrier-free version of this antibody is also available. 

                            >>Beta-amyloid and tau tools and reagents



                            The role of astrocytes in Alzheimer's disease​


                            Learn more about the role of astrocytes in AD from Professor Shane Liddelow, Principal Investigator at the Liddelow lab.
                            ​​


                            Solutions to support Alzheimer's disease research

                            Achieve results faster with high-quality, disease-relevant products.

                            From recombinant antibodies to high-throughput assays, we provide a wide range of solutions to support your Alzheimer's research and enable you to be ready for the next stage in your discovery pipeline.

                            Explore the table below to learn more about our premium product ranges.

                            ​


                            Highlighted products

                            Recombinant antibodies

                            Achieve superior batch-to-batch consistency and unrivaled specificity with our recombinant antibodies

                            Anti-Tau (ab32057)

                            Anti-Tau aggregates (ab246808)

                            Anti-Tau pT231 (ab151559)

                            Carrier-free and primary conjugated antibodies

                            With an extensive range of labels, enjoy the freedom of creating a workflow that will take you swiftly from start to finish.

                            Anti-NeuN Alexa Fluor® 647 (ab190565) 

                            Anti-TMEM119 Alexa Fluor® 488 (ab225497)

                            Recombinant proteins and peptides

                            Our class-leading recombinant proteins have an unrivaled specification and are ideal for preclinical cell culture and functional studies.

                            beta-amyloid peptide (1-42) (ab120301)

                            IL-1 beta protein (active) (ab259387)

                            Biochemicals

                            Biochemicals are powerful tools for probing biological systems. Explore our highly-cited biochemical range to support your program.

                            GSK3-beta inhibitor (ab120853)

                            Calcium assay kit (ab102505)

                            Gene-edited cell lines

                            Save time and advance your discovery workflow with reliable and well-characterized gene-edited cell lines.

                            Human APP KO HEK-293T (ab255362)

                            Human iPSC-derived cells

                            Access highly-defined and consistent hiPSCs for research, drug discovery, and high-throughput screening.

                            ioGlutamatergic neurons (ab259259)

                            ioSkeletal myocytes (ab277612)

                            ELISA kits

                            Get the most out of your research and high-throughput screening with our ELISA-based tools.

                            Human/mouse/rat NEFL ELISA pair (ab253512)

                            Human TREM2 ELISA pair (ab224881)

                            FirePlex assays

                            Our unique FirePlex multiplex assays and antibody arrays offer enhanced protein and miRNA analysis in class-leading high-throughput formats (384- and 1536-well plates).

                            Key cytokines panel (ab243549)

                            Neurology miRNA panel V2 (ab218371)




                            References


                            1. Alzheimer’s Research UK. Dementia Statistics Hub - Global Prevalence. Available at: https://www.dementiastatistics.org/statistics/global-prevalence/.
                            ​​






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