For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

We use cookies to make our site as useful as possible.

Our Cookie Policy explains how you can opt-out of the cookies we use.

If you continue without changing your cookie settings, we'll assume you’re happy with this.

Continue Continue

United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Diagnostic & Therapeutic Solutions
    Custom solutions & partnerships

    Custom antibody development and commercial partnerships to advance your diagnostic and therapeutic discovery.

    Create custom solutions with us

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

Supporting our customers and employees during the COVID-19 pandemic. Read more

Amyotrophic Lateral Sclerosis: overview, antibodies, and disease-related markers

Related

  • Huntington's disease treatment
    • Alzheimer's disease: antibodies, tools, and support
      • Parkinson's disease overview and research tools
        • Multiple sclerosis research landscape
          • Neural markers guide

            Explore ALS and access the tools you need to support your research.  

            • What is Amyotrophic lateral sclerosis?
            • Interactive ALS pathway
            • Recombinant monoclonal antibodies and proteins for ALS disease research
            • Disease-associated markers
            • Other key cell and neuronal markers from Abcam
            • References

            What is Amyotrophic lateral sclerosis? 

            ​​​​​​​​Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig’s disease, is an adult-onset, progressive, neurological disease that results in the destruction of neurons which control voluntary muscles, namely those in the motor cortex, brainstem, and spinal cord.

            The pathological hallmark of ALS is the presence of inclusion bodies (abnormal aggregations of protein) in the cytoplasm of motor neurons. In the vast majority of cases, the main component of the inclusion bodies is TDP-43 protein, however, in those with SOD1 or FUS mutations, the main component is SOD1 protein or FUS protein, respectively1,2.

            Genetic studies have implicated deficits in autophagy and/or mitophagy in the onset of the disease3.

            Amyotrophic lateral sclerosis –​ interactive pathway 

            Study key genes and molecular mechanisms involved in the development of ALS with our interactive poster, which will help you find the best tools for your research in ALS.

            Click on the preview image below to download our interactive pathway.

            ​​​​​

            ​​​​​​Recombinant monoclonal antibodies and proteins for ALS disease research

            Get reproducible, batch-to-batch consistency using recombinant monoclonal antibodies and proteins for your ALS research. These are some of our best-selling products. 

            Antibodies

            GeneTargetabIDApplicationSpecies
            C9ORF72C9ORF72ab221137WBMouse, Rat, Human
            FUSTLS/FUSab124923WB, IHC-P, Flow Cyt, ICC/IFMouse, Rat, Human
            SOD1Superoxide dismutaseab51254WB, Flow Cyt, IHC-P, ICC/IFRat, Human
            VCPVCPab109240WB, IP, IHC-P, Flow Cyt, ICC/IFMouse, Rat, Human
            TARDBPTDP43ab109535ICC/IF, Flow Cyt, IHC-Fr, WB, IHC-PMouse, Rat, Human


            Proteins

            Target

            SpeciesExpression systemabID

            Superoxide Dismutase 1

            HumanEscherichia coliab84642

            VCP

            HumanBaculovirus infected Sf9 cellsab269130

            TDP43

            HumanEscherichia coliab269030
            ​


            Disease-associated markers 

            ​To help you get ahead in your ALS research, we’ve compiled the best markers to use in conjunction with our disease-specific antibodies.

            GeneTargetabIDApplicationSpecies
            ISL1Islet 1ab109517IHC-Fr, ICC/IF, WB, IP, Flow CytMouse, Chicken, Human
            VIM Vimentinab92547ICC/IF, WB, Flow Cyt, IHC-P, IHC-FrMouse, Rat, Human, Rhesus monkey

            Other key cell and neuronal markers from Abcam 

            Check out our range of neuronal markers for supporting your research.

            Neural markersMarker groupRecommended product
            Ki67Proliferating cell markerab16667
            GFAPSchwann cell/radial glia/astrocyteab33922, ab68428
            VIMRadial gliaab92547
            NeuNMature neuronab177487
            MAP2Mature neuronab183830
            TUBB3Immature neuronab78078
            MBPOligodendrocyteab218011
            PSD95Mature neuronab18258
            NESRadial gliaab105389
            DCXImmature neuronab18723
            SYPMature neuronab32127
            NOTCH1Astrocyteab52627
            THDopaminergic neuronab137869
            S100BAstrocyteab52642
            MAPTMature neuron/axonsab80579, ab32057, ab109390 (phospho S396)

            References

            1. Saberi, S., Stauffer, J.E., Schulte, D.J., Ravits, J. Neuropathology of amyotrophic lateral sclerosis and its variants. Neurol Clin. 33, 855–876 (2015).
            2. Blokhuis, A.M., Groen, E.J., Koppers, M., van den Berg, L.H., Pasterkamp, R.J. Protein aggregation in amyotrophic lateral sclerosis. Acta Neuropathol. 125, 777
            –794 (2013).
            3. Evans, C.S., Holzbaur, E.L.F. Autophagy and mitophagy in ALS. Neurobiol. Dis. 122, 35–40 (2019).  ​






            Get resources and offers direct to your inbox Sign up
            A-Z by research area
            • Cancer
            • Cardiovascular
            • Cell biology
            • Developmental biology
            • Epigenetics & Nuclear signaling
            • Immunology
            • Metabolism
            • Microbiology
            • Neuroscience
            • Signal transduction
            • Stem cells
            A-Z by product type
            • Primary antibodies
            • Secondary antibodies
            • Biochemicals
            • Isotype controls
            • Flow cytometry multi-color selector
            • Kits
            • Loading controls
            • Lysates
            • Peptides
            • Proteins
            • Slides
            • Tags and cell markers
            • Tools & Reagents
            Help & support
            • Support
            • Make an Inquiry
            • Protocols & troubleshooting
            • Placing an order
            • RabMAb products
            • Biochemical product FAQs
            • Training
            • Browse by Target
            Company
            • Corporate site
            • Investor relations
            • Company news
            • Careers
            • About us
            • Blog
            Events
            • Tradeshows
            • Conferences
            International websites
            • abcam.cn
            • abcam.co.jp

            Join with us

            • LinkedIn
            • facebook
            • Twitter
            • YouTube
            • Terms of sale
            • Website terms of use
            • Cookie policy
            • Privacy policy
            • Legal
            • Modern slavery statement
            © 1998-2021 Abcam plc. All rights reserved.