Astrocyte markers (성상세포 마커)
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Astrocyte marker 관련 한 눈에 보는 가이드
Astrocyte marker는 중추신경계에서 다양한 기능을 수행하는 별 모양의 아교세포입니다. 이는 뇌 발달, 생리학, 병리학에 중요합니다.
GFAP
Glial fibrillary acidic protein (GFAP)는 intermediate filament로서 astrocyte cytoskeleton의 주요 성분입니다.
추천 항체: Recombinant Anti-GFAP antibody [EPR1034Y] (ab68428)
Image (left): Human hippocampus tissue section stained with anti-GFAP (ab68428).
GFAP antibodies 전체 리스트 보기
EAAT1/GLAST
Excitatory amino acid transporter 1 (EAAT1)는 astrocyte 특이적 glutamate transporter입니다. 또한 glutamate aspartate Transporter (GLAST)로 알려져 있을 수 있습니다.
추천 항체: Recombinant Anti-EAAT1 antibody [EPR12686] (ab181036)
Selective EAAT1 inhibitors 추천: UCPH-101 (ab120309) and UCPH-102 (ab146404)
Image (left): Rat cerebral cortex tissue sections stained with anti-EAAT1 (ab181036).
EAAT1/GLAST antibodies 전체 리스트 보기
EAAT2/GLT-1
Excitatory amino acid transporter 2 (EAAT2)는 astrocyte 특이적 glutamate transporter입니다. EAAT2 는 solute carrier family 1 member 2 (SLC1A2)와 glutamate transporter 1 (GLT-1)과 같은 여러 이름을 가지고 있습니다.
추천 항체: Recombinant Anti-EAAT2 antibody [EPR19798] (ab205248)
| Biochemical | Recommended product |
| Selective EAAT2 inhibitor | Dihydrokainic acid (ab120066) |
| Stimulator of EAAT2 expression | Ceftriaxone (ab120871) |
| Potent and competitive EAAT1-4 inhibitor | L-(-)-threo-3-Hydroxyaspartic acid (ab146130) |
| Potent and competitive EAAT2, EAAT4 and EAAT5 inhibitor | L-trans-Pyrrolidine-2,4-dicarboxylic acid (ab146131) |
Image (left): Mouse striatum tissue sections stained with anti-EAAT2 (green) (ab205248).
EAAT2/GLT-1 antibodies 전체 리스트 보기
Glutamine synthetase
이 효소는 질소 대사에 관여합니다. 뇌에서는 주로 astrocyte에서 발견됩니다.
추천 항체: Recombinant Anti-Glutamine Synthetase antibody [EPR13022(B)] (ab176562)
Image (left): Mouse cerebrum tissue sections stained with anti-glutamine synthetase (green) (ab176562).
Glutamine synthetase antibodies 전체 리스트 보기
S100 beta
S100 beta는 oligodendrocyte precursor cells (OPCs)에서도 발견되는 칼슘 결합 단백질입니다. NG2와 함께 이중 표지(double labeling)를 하면 astrocyte로부터 OPCs를 구별해낼 수 있습니다.
추천 항체: Recombinant Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642)
Image (left): Rat cerebrum tissue sections stained with anti-S100 beta (green) (ab52642).
S100 beta antibodies 전체 리스트 보기
ALDH1L1
Aldehyde dehydrogenase 1 family member L1(ALDH1L1)는 10-formyltetrahydrofolate, NADP+, 물을 tetrahydrofolate, NADPH, CO2로 변환하는 것을 촉매하는 효소입니다.
추천 항체: Recombinant Anti-ALDH1L1 antibody [EPR12743(B)] (ab177463)
Image (left): Human kidney tissue sections stained with anti-ALDH1L1 (ab177463).
ALDH1L1 antibodies 전체 리스트 보기
References
- Abrahamsen, B. et al. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J. Neurosci. 33, 1068–87 (2013).
- Cahoy, J. D. et al. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J. Neurosci. 28, 264–78 (2008).
- Dimou, L. & Götz, M. Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain. Physiol. Rev. 94, 709–737 (2014).
- Kriegstein, A. R. & Götz, M. Radial glia diversity: A matter of cell fate. Glia 43, 37–43 (2003).
- Lee, S.-G. et al. Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes. J. Biol. Chem. 283, 13116–23 (2008).
- Medrano, M. C., Gerrikagoitia, I., Martínez-Millán, L., Mendiguren, A. & Pineda, J. Functional and morphological characterization of glutamate transporters in the rat locus coeruleus. Br. J. Pharmacol. 169, 1781–94 (2013).
- Shigeri, Y. et al. Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J. Neurochem. 79, 297–302 (2008).