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Cholinergic neurons use the neurotransmitter acetylcholine. Their progressive loss is one of the hallmarks of neurodegenerative diseases with cognitive deficits such as Alzheimer’s disease.
Choline acetyltransferase (ChAT)
An enzyme that catalyzes the synthesis of acetylcholine.
Mouse spinal cord sections stained with anti-choline acetyltransferase (ab178850).
Choline acetyltransferase modulators
|Choline chloride (ab145788)||Choline acetyltransferase substrate|
Fluorescent, selective, non-competitive slowly reversible ChAT inhibitorFluorescent, selective, non-competitive slowly reversible ChAT inhibitor
Vesicular acetylcholine transporter (VAChT)
A transporter that uses a proton gradient established by the vacuolar ATPase to transport acetylcholine into secretory vesicles.
Guinea pig ileum stained with anti-vesicular acetylcholine transporter (ab31544).