Conformation-specific amyloid beta antibodies

Explore our range of antibodies for distinguishing conformational variation in amyloid structures.

In Alzheimer's disease, amyloid beta (Aß) plaques exhibit diverse conformations resulting in structural variants with distinct pathologies. In collaboration with Professor Charles Glabe (UC Irvine), we developed rabbit monoclonal antibodies against Aß 1–42 fibrils that can distinguish conformational variation in amyloid structures.

  • Human Aß (1–42) fibril immunogen
  • Rabbit monoclonal antibodies for high affinity and specificity
  • Validated using dot blot and IHC-P
  • Published in The Journal of Biological Chemistry

Antibody reactivity in human and mouse Alzheimer's disease brain

Antibody nameAntibody IDHuman Alzheimer's brain specificity shown by IHC**Alzheimer's mouse model* brain specificity shown by IHC**
Anti-amyloid fibril antibody [mOC22] - conformation-specificab205339Frontal cortex plaquesLayer V cortical and CA1 pyramidal neurons
Anti-beta amyloid 1-42 antibody [mOC23] - conformation specific ab205340Subset of frontal cortex plaquesHippocampal plaques

Anti-beta amyloid 1-42 antibody [mOC31] - conformation-specific

ab201059Vascular amyloid depositsN/A
Anti-beta amyloid 1-4 antibody [mOC64] - conformation-specificab201060Frontal cortex plaquesN/A
Anti-amyloid fibril antibody [mOC78] - conformation specificab205341Intracellular/nuclear, frontal cortex plaquesLayer V cortical neurons
Anti-amyloid fibril antibody [mOC87] - conformation-specificab201062Frontal cortex plaquesLayer V cortical neurons (intracellular deposits)
Anti-beta amyloid 1-42 antibody [mOC98] - conformation-specificab201061Frontal cortex plaquesLayer V cortical neurons (intracellular deposits)
Anti-amyloid fibril antibody [mOC116] - conformation specificab205342Frontal cortex plaquesLayer V cortical neurons, ​hippocampal plaques​

*14 month-old 3xTg-AD mouse model of Alzheimer's disease
** IHC shown in Hatami et al. 2014

Sign up