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Fluid biomarkers in neurodegenerative disorders

Related

  • Alzheimer's disease
    • Parkinson's disease
      • Traumatic Brain Injury
        • Neural markers
          • Recombinant antibodies: success at first trial

            Fluid biomarkers are measures of physiological or pathogenic processes detected in biological fluids such as cerebrospinal fluid (CSF) and plasma. They have become an integral part of the clinical diagnosis and prognosis of neurodegenerative disorders and transformed how therapeutic effects are monitored in clinical trials. The use of fluid biomarkers is particularly important in the early diagnosis of neurological diseases. 

            For example, CSF analysis can reveal changes in the ratio levels of amyloid beta (Aβ)42/40 or total/phosphorylated tau which might indicate the development of Alzheimer’s disease (AD) in a patient. Changes in the levels of neurofilament light are also emerging as a broad biomarker of neurodegeneration across a wide range of diseases.

            ​

            Explore key biomarkers in neurodegeneration

            The poster below identifies some of the key biomarkers in neurodegeneration. Biomarkers for protein misfolding, neuronal injury, synaptic damage, Inflammation and vascular dysregulation can be found on the poster.

            Fluid Biomarkers in traumatic brain injury and Alzheimer's disease

            Presented by Kaj Blennow, MD, PhD, Professor and Chief Physician, Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Gothenburg University. Kaj talks about the need for fluid biomarker testing and highlights some key biomarkers of interest in traumatic brain injury, concussion and Alzheimer's disease. 


            Fluid Biomarkers in neuroinflammation - Alzheimer's disease

            Presented by Michael Heneka, MD, Professor for Clinical Neurology and Neuroscience, University of Bonn Medical Center, DZNE. Michael talks about the ongoing need to gather more information on neuroinflammation.  He explains that there are multiple types of inflammation which are found in different areas of the brain and that there is a need for precise biomarkers to be used in research and diagnostics.

            Presented by Kaj Blennow, MD, PhD, Professor and Chief Physician, Neurochemistry laboratory, Institute of Neuroscience and Physiology, Gothenburg Universi


            Recombinant monoclonal antibodies and SimpleStep ELISA® kits

            Get reproducible, batch-to-batch consistency using SimpleStep ELISA® kits and recombinant monoclonal antibodies for your biomarker research. Here we’ve highlighted some of our key products to support your research. We have selected products relating to key biomarkers including Tau, LRKK2, TREM2 and important inflammatory cytokines, among others.


            Synaptic damage




            SimpleStep ELISA® kit Antibody
            SNAP25ab256394

            ab109105

            Neurograninab277083ab217672
            Neurogranin truncated P75ab277084
            GAP-43

            ab75810

            Synaptophysin

            ab32127

            SV2A
            ab254351
            Synapsin-1
            ab254349

            Neuronal injury




            SimpleStep ELISA® kitAntibody
            Neurofilament light

            ab223343

            VLIP-1

            ab180141

            S100bab234573

            ab52642

            NSEab217778

            ab180943

            Protein misfolding markers




            SimpleStep ELISA® kitAntibody
            Tau

            ab254256

            Tau tangles
            ab246808
            Tau pT231
            ab151559
            Tau pS404
            ab92676
            Tau pT181

            ab223192

            Beta amyloid 1-40ab193692ab76317
            Beta amyloid 1-42

            ab201061

            Alpha-synucleinab260052

            ab138501

            Alpha-synuclein aggregates
            ab209538
            Alpha-synuclein pS129
            ab51253
            TDP-43

            ab109535

            ab190963

            Inflammation




            SimpleStep ELISA® kitAntibody
            TREM2ab224881ab209814
            YKL-40ab255719ab255297
            IL1-βab229384

            ab216995

            IL-6ab178013

            ab233706

            IL-8ab214030

            ab110727

            IFN-γ

            ab236895 (High Sensitivity)

            ab231036
            MCP-1/CCL2ab179886ab214819
            Eotaxin
            ab133604
            CX3CL1/Fractalkineab192145
            TNF-α

            ab181421

            ab215188

            GFAPab223867

            ab68428

            TGF-β

            ab215715

            ​​​​

            Vascular dysregulation




            SimpleStep ELISA® kitAntibody
            CRP

            ab278042   Fluorescent

            ab32412

            VCAM1/CD106ab223591

            ab134047

            ICAM1/CD54

            ab229383 CatchPoint

            ab109361

            Flt-1/sVEGF-R1ab195210ab32152
            VEGF-Aab222510ab52917
            ​​


            Pharmacodynamic biomarkers




            SimpleStep ELISA® kitAntibody
            LRKK2

            ab133474

            LRKK2 pS1292

            ab133450

            Rab8ab255718

            ab188574

            Rab8 pT72
            ab230260
            Rab10ab255717

            ab237703

            Rab10 pT73

            ab241060

            Rab12 pS106
            ab256487

            ​



            ​




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