Fluid biomarkers in neurodegenerative disorders

Fluid biomarkers are measures of physiological or pathogenic processes detected in biological fluids such as cerebrospinal fluid (CSF) and plasma. They have become an integral part of the clinical diagnosis and prognosis of neurodegenerative disorders and transformed how therapeutic effects are monitored in clinical trials. The use of fluid biomarkers is particularly important in the early diagnosis of neurological diseases. 

For example, CSF analysis can reveal changes in the ratio levels of amyloid beta (Aβ)42/40 or total/phosphorylated tau which might indicate the development of Alzheimer’s disease (AD) in a patient. Changes in the levels of neurofilament light are also emerging as a broad biomarker of neurodegeneration across a wide range of diseases.

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Explore key biomarkers in neurodegeneration

The poster below identifies some of the key biomarkers in neurodegeneration. Biomarkers for protein misfolding, neuronal injury, synaptic damage, Inflammation and vascular dysregulation can be found on the poster.

Fluid Biomarkers in traumatic brain injury and Alzheimer's disease

Presented by Kaj Blennow, MD, PhD, Professor and Chief Physician, Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Gothenburg University. Kaj talks about the need for fluid biomarker testing and highlights some key biomarkers of interest in traumatic brain injury, concussion and Alzheimer's disease. 

Fluid Biomarkers in neuroinflammation - Alzheimer's disease

Presented by Michael Heneka, MD, Professor for Clinical Neurology and Neuroscience, University of Bonn Medical Center, DZNE. Michael talks about the ongoing need to gather more information on neuroinflammation.  He explains that there are multiple types of inflammation which are found in different areas of the brain and that there is a need for precise biomarkers to be used in research and diagnostics.

Recombinant monoclonal antibodies and SimpleStep ELISA^® kits

Get reproducible, batch-to-batch consistency using SimpleStep ELISA^® kits and recombinant monoclonal antibodies for your biomarker research. Here we’ve highlighted some of our key products to support your research. We have selected products relating to key biomarkers including Tau, LRKK2, TREM2 and important inflammatory cytokines, among others.

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