GABAergic neuron markers
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Discover commonly used markers for GABAergic neurons to use in your research.
GABAergic neurons produce gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS).
GABA is primarily synthesized from glutamate, catalyzed by glutamate decarboxylase (GAD), and is present at 30 - 40% of synapses. GABA induces either Cl- influx or K+ efflux, resulting in hyperpolarized neurons and reduced action potential.
Dysfunction of GABA neurotransmission can result in several disorders, including schizophrenia and epilepsy.
- GABA transporter 1 (GAT1)
- GABAB receptors 1 and 2
- Glutamate decarboxylase isoforms (GAD65 and GAD67)
GABA transporter 1 (GAT1)
GABA transporter 1 (GAT1)
A transporter on the cell membrane that moves GABA into the cell, removing it from the synaptic cleft.
Mouse brain tissue sections stained with anti-GABA transporter 1 (ab64645).
Browse all GABA transporter 1 antibodies
GAT1 inhibitors
| Product | Activity |
| NNC 711 (ab120364) | Potent, selective GAT1 inhibitor Potent, selective GAT-1 inhibitor |
| Tiagabine hydrochloride (ab120237) | Selective GAT1 inhibitor |
GABAB receptors 1 and 2
GABAB receptors are metabotropic transmembrane receptors for GABA that are linked via G-proteins to potassium channels. GABAB receptor 1 and GABAB receptor 2 assemble as heterodimers in neuronal membranes.
Rat brain (hippocampus) stained with anti-GABAB receptor 1 (red) (ab55051).
GABAB receptor modulators
| Product | Activity |
| Saclofen (ab120327) | Selective GABAB receptor agonist |
| (R)-Baclofen (ab120325) | GABAB receptor agonist |
| CGP 35348 (ab120167) | GABAB receptor agonist |
| CGP 7930 (ab120492) | Positive GABAB receptor allosteric modulator |
| GS 39783 (ab120320) | Novel GABAB positive allosteric modulator |
GAD65
The 65 kDa isomorph of glutamate decarboxylase that catalyzes the formation of GABA from glutamate.
Rat cerebellar cortex labeled with anti-GAD65 (ab26113).
GAD67
The 67 kDa isomorph of glutamate decarboxylase. Unlike GAD65, which is also expressed in the pancreas, GAD67 is CNS-specific.
Mouse cerebellum sections stained with anti-GAD67 (ab26116).
References
- Adams, C. L. & Lawrence, A. J. CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Rev. 13, 308–16 (2007).
- Bettler, B., Kaupmann, K., Mosbacher, J. & Gassmann, M. Molecular structure and physiological functions of GABA(B) receptors. Physiol. Rev. 84, 835–67 (2004).
- Bráz, J. M. et al. Forebrain GABAergic Neuron Precursors Integrate into Adult Spinal Cord and Reduce Injury-Induced Neuropathic Pain. Neuron 74, 663–675 (2012).
- Misgeld, U., Bijak, M. & Jarolimek, W. A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. Prog. Neurobiol. 46, 423–62 (1995).
- Obrietan, K. & van den Pol, A. N. GABAB receptor-mediated inhibition of GABAA receptor calcium elevations in developing hypothalamic neurons. J. Neurophysiol. 79, 1360–70 (1998).
- Rey, A. A., Purrio, M., Viveros, M.-P. & Lutz, B. Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. Neuropsychopharmacology 37, 2624–2634 (2012).
- Volk, D. W., Sampson, A. R., Zhang, Y., Edelson, J. R. & Lewis, D. A. Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders. Psychol. Med. 46, 2501–2512 (2016).
- Zhou, Y. & Danbolt, N. C. GABA and Glutamate Transporters in Brain. Front. Endocrinol. (Lausanne). 4, 165 (2013).