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GABAergic neuron markers

Related

  • Back to neural markers guide
    • Directly conjugated neural markers
      • GABA receptor agonists, activators, antagonists and inhibitors
        • Your guide to optimizing IHC experiments
          • Caged neurotransmitters for precision release
            • Sign up for the latest research resources
              • GABAergic primary antibodies
                • GABA transporter 1 primary antibodies
                  • GABA B receptor 1 & 2 primary antibodies
                    • GAD65 primary antibodies
                      • GAD67 primary antibodies

                        Discover commonly used markers for GABAergic neurons to use in your research.

                        ​​GABAergic neurons produce gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS).

                        GABA is primarily synthesized from glutamate, catalyzed by glutamate decarboxylase (GAD), and is present at 30 - 40% of synapses. GABA induces either Cl- influx or K+ efflux, resulting in hyperpolarized neurons and reduced action potential. 

                        Dysfunction of GABA neurotransmission can result in several disorders, including schizophrenia and epilepsy. 

                        • GABA transporter 1 (GAT1)
                        • GABAB​ receptors 1 and 2 
                        • Glutamate decarboxylase isoforms (GAD65 and GAD67)


                        GABA transporter 1 (GAT1)

                        ​GABA transporter 1 (GAT1)

                        A transporter on the cell membrane that moves GABA into the cell, removing it from the synaptic cleft.

                        Mouse brain tissue sections stained with anti-GABA transporter 1 (ab64645).

                        ​Browse all GABA transporter 1 antibodies


                        GAT1 inhibitors

                        ProductActivity
                        NNC 711 (ab120364)​​Potent, selective GAT1 inhibitor
                        Potent, selective GAT-1 inhibitor
                        Tiagabine hydrochloride (ab120237)Selective GAT1 inhibitor


                        GABAB receptors 1 and 2 

                        ​​GABAB receptors 1 and 2

                        GABAB receptors are metabotropic transmembrane receptors for GABA that are linked via G-proteins to potassium channels. GABA​B receptor 1 and GABAB receptor 2 assemble as heterodimers in neuronal membranes.

                        Rat brain (hippocampus) stained with anti-GABAB receptor 1 (red) (ab55051).

                        Browse all GABAB1 antibodies

                        Browse all GABAB2 antibodies

                        ​

                        GABAB receptor modulators

                        ProductActivity
                        Saclofen (ab120327)Selective GABAB receptor agonist
                        (R)-Baclofen (ab120325)GABAB receptor agonist
                        CGP 35348 (ab120167)GABAB receptor agonist
                        CGP 7930 (ab120492)Positive GABAB receptor allosteric modulator
                        GS 39783 (ab120320)Novel GABAB positive allosteric modulator


                        Glutamate decarboxylase isoforms (GAD65 and GAD67)

                        GAD65
                        The 65 kDa isomorph of glutamate decarboxylase that catalyzes the formation of GABA from glutamate.

                        Rat cerebellar cortex labeled with anti-GAD65 (ab26113).

                        Browse all GAD65 antibodies


                        GAD67
                        The 67 kDa isomorph of glutamate decarboxylase. Unlike GAD65, which is also expressed in the pancreas, GAD67 is CNS-specific.

                        Mouse cerebellum sections stained with anti-GAD67 (ab26116).

                        Browse all GAD67 antibodies



                        References 

                        • Adams, C. L. & Lawrence, A. J. CGP7930: a positive allosteric modulator of the GABAB receptor. CNS Drug Rev. 13, 308–16 (2007).
                        • Bettler, B., Kaupmann, K., Mosbacher, J. & Gassmann, M. Molecular structure and physiological functions of GABA(B) receptors. Physiol. Rev. 84, 835–67 (2004).
                        • Bráz, J. M. et al. Forebrain GABAergic Neuron Precursors Integrate into Adult Spinal Cord and Reduce Injury-Induced Neuropathic Pain. Neuron 74, 663–675 (2012).
                        • Misgeld, U., Bijak, M. & Jarolimek, W. A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. Prog. Neurobiol. 46, 423–62 (1995).
                        • Obrietan, K. & van den Pol, A. N. GABAB receptor-mediated inhibition of GABAA receptor calcium elevations in developing hypothalamic neurons. J. Neurophysiol. 79, 1360–70 (1998).
                        • Rey, A. A., Purrio, M., Viveros, M.-P. & Lutz, B. Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABAB Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. Neuropsychopharmacology 37, 2624–2634 (2012).
                        • Volk, D. W., Sampson, A. R., Zhang, Y., Edelson, J. R. & Lewis, D. A. Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders. Psychol. Med. 46, 2501–2512 (2016). 
                        • Zhou, Y. & Danbolt, N. C. GABA and Glutamate Transporters in Brain. Front. Endocrinol. (Lausanne). 4, 165 (2013).


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