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GABAergic neurons produce gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS).
GABA is primarily synthesized from glutamate, catalyzed by glutamate decarboxylase (GAD), and is present at 30 - 40% of synapses. GABA induces either Cl- influx or K+ efflux, resulting in hyperpolarized neurons and reduced action potential.
Dysfunction of GABA neurotransmission can result in several disorders, including schizophrenia and epilepsy.
A transporter on the cell membrane that moves GABA into the cell, removing it from the synaptic cleft.
Mouse brain tissue sections stained with anti-GABA transporter 1 (ab64645).
Browse all GABA transporter 1 antibodies
Product | Activity |
NNC 711 (ab120364) | Potent, selective GAT1 inhibitor Potent, selective GAT-1 inhibitor |
Tiagabine hydrochloride (ab120237) | Selective GAT1 inhibitor |
GABAB receptors are metabotropic transmembrane receptors for GABA that are linked via G-proteins to potassium channels. GABAB receptor 1 and GABAB receptor 2 assemble as heterodimers in neuronal membranes.
Rat brain (hippocampus) stained with anti-GABAB receptor 1 (red) (ab55051).
Product | Activity |
Saclofen (ab120327) | Selective GABAB receptor agonist |
(R)-Baclofen (ab120325) | GABAB receptor agonist |
CGP 35348 (ab120167) | GABAB receptor agonist |
CGP 7930 (ab120492) | Positive GABAB receptor allosteric modulator |
GS 39783 (ab120320) | Novel GABAB positive allosteric modulator |
Rat cerebellar cortex labeled with anti-GAD65 (ab26113).
Mouse cerebellum sections stained with anti-GAD67 (ab26116).
References