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Glutamatergic neurons produce glutamate, which is one of the most common excitatory neurotransmitters in the central nervous system (CNS).
It plays a critical role in fundamental processes, such as learning, cognition, and memory, and dysregulation of glutamatergic transmission can result in several neurological conditions.
There are several well-characterized glutamatergic neuron markers, which can help you identify your neuronal population.
You may also be interested in our human iPSC-derived glutamatergic neurons.
Vesicular glutamate transporters transport cytoplasmic glutamate into synaptic vesicles. There are three mammalian glutamate transporters, vGluT1 – VGluT3, which have partially overlapping expression patterns.
NMDA receptors are ion channels that are activated by glutamate and glycine. They play an important role in many neuronal functions, including synaptic plasticity, synaptogenesis, and memory.
Another NMDA receptor subunit. This subunit forms the glutamate binding site on the NMDA receptors.
Mouse cerebral cortex sections stained with anti-NMDAR2B (ab65783).
|NGHVYEKLSSIE (Interfering peptide) (ab120380)|
Peptide (agonist) that competes with clathrin adaptor protein (AP-2) binding to NR2B.
Non-competitive specific inhibitor of NMDAR1 and/or NMDAR2B subunits.
Downregulates GluN2B-containing NMDA receptors in the NAc.
|Ro 25-6981 maleate salt (ab120290)|
Potent, highly selective, activity-dependent inhibitor of NMDA receptors that contain the NR2B subunit.
|Ifenprodil hemitartrate (ab120111)|
Non-competitive NMDAR2B antagonist acting at the polyamine site.
An enzyme catalyzing the ATP-dependent amidation of glutamate to form glutamine. It is primarily expressed in astrocytes but expression levels rise in neurons in neurodenegerative diseases. When staining for glutamine synthetase, we recommend parallel use of NeuN.
Zebrafish retina sections stained with anti-glutamine synthetase (purple) (ab93439).