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Explore Huntington’s disease and access the tools you need to better understand this complex condition.
Professor Roger Barker
Professor Roger Barker (Professor of Clinical Neuroscience, University of Cambridge) has recorded a talk for us on the current and future landscape of Huntington’s treatment. Professor Barker explains how this is a very exciting time for Huntington’s Disease research, we are now more able than ever before to diagnose when the disease process has started, which informs us of the optimal time to begin treating patients.
Professor Barker also discusses how the intrathecal injection of antisense oligonucleotides (ASO) can be used to reduce the production of all forms of the Huntingtin protein. This approach has shown great potential to slow down or reverse Huntington's disease. He also talks about alternative ongoing research using autophagy to increase the clearance of the abnormal protein which causes Huntington's disease.
Finally, Professor Barker explains how using these two approaches together could be additive and work synergistically to reduce the protein that is causing the disease and thereby stop the disease process.
11:21 minutes - Professor Roger Barker, Professor of Clinical Neuroscience, University of Cambridge.
See our range of Huntingtin products here.
Recombinant monoclonal antibodies and proteins for Huntington's disease research
Get reproducible, batch-to-batch consistency using recombinant monoclonal antibodies and proteins for your HD research. These are a selection of our best selling products for some of the most important HD targets.
|Gene name||Target name||AbID||Applications||Species|
|HTT||Huntingtin||ab109115||Flow Cyt, IHC-FoFr, ICC/IF, WB, IHC-P||Mouse, Rat, Human|
|Grin1||NMDAR1||ab109182||WB, ICC/IF||Mouse, Rat, Human|
|PDE10A||PDE10A||ab227829||WB, IHC-Fr, IP||Mouse, Rat, Human|
|Target name||AbID||Species||Expression system|
Antibody sampler panels
Our Huntington's disease antibody sampler panels allow you to try different antibody clones for key Huntington's disease targets to help you pick the right antibody for your research. Each panel contains 20µl aliquots of at least five different antibody clones.
|Autophagy Marker Antibody Sampler Panel||Autophagy Antibody Panel Sampler Panel contains multiple trial-sized versions of clones against APG5L/ATG5, ATG16L1, ATG4B, ATG9A, Beclin 1, and LC3B specifically selected for high performance in various applications.||ab228525|
|Autophagy Analysis Antibody Sampler Panel contains multiple trial-sized versions of anti-human, mouse and rat antibody clones against ATG16L1, ATG16L1 pS278, SQSTM1, LC3B, Ubiquitin and M6PR, specifically selected for high performance in various applications.||ab269811|
Key cell and neuronal markers from Abcam
To help you get ahead in your Huntington’s research, we’ve compiled the best neuronal markers to use in conjunction with our disease-specific antibodies.
|Neural markers||Marker group||Recommended product|
|Ki67||Proliferating cell marker||ab16667|
|GFAP||Schwann cell/radial glia/astrocyte||ab33922, ab68428|
|MAPT||Mature neuron/axons||ab80579, ab32057, ab109390 (phospho S396)|