Huntington's disease treatment: the current and future landscape
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Professor Roger Barker
Professor Roger Barker (Professor of Clinical Neuroscience, University of Cambridge) has recorded a talk for us on the current and future landscape of Huntington’s treatment. Professor Barker explains how this is a very exciting time for Huntington’s Disease research, we are now more able than ever before to diagnose when the disease process has started, which informs us of the optimal time to begin treating patients.
Professor Barker also discusses how the intrathecal injection of antisense oligonucleotides (ASO) can be used to reduce the production of all forms of the Huntingtin protein. This approach has shown great potential to slow down or reverse Huntington's disease. He also talks about alternative ongoing research using autophagy to increase the clearance of the abnormal protein which causes Huntington's disease.
Finally, Professor Barker explains how using these two approaches together could be additive and work synergistically to reduce the protein that is causing the disease and thereby stop the disease process.
11:21 minutes - Professor Roger Barker, Professor of Clinical Neuroscience, University of Cambridge.
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