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Huntington's disease treatment: the current and future landscape

Related

  • See our range of Huntingtin products
    • See our range of NMDAR products
      • See our Autophagy Marker Antibody Panel
          • Neural markers guide
            • View our GFAP range
                • Autophagy overview
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                              ​
                              Explore Huntington’s disease and access the tools you need to better understand this complex condition.​​

                              ​

                              ​​Overview

                              • Professor Roger Barker
                              • Recombinant monoclonal antibodies and proteins for Huntington's disease research
                              • Antibody sampler panels
                              • Key cell and neuronal markers from Abcam​

                              Professor Roger Barker

                              Professor Roger Barker (Professor of Clinical Neuroscience, University of Cambridge) has recorded a talk for us on the current and future landscape of Huntington’s treatment. Professor Barker explains how this is a very exciting time for Huntington’s Disease research, we are now more able than ever before to diagnose when the disease process has started, which informs us of the optimal time to begin treating patients.  

                              Professor Barker also discusses how the intrathecal injection of antisense oligonucleotides (ASO) can be used to reduce the production of all forms of the Huntingtin protein. This approach has shown great potential to slow down or reverse Huntington's disease. He also talks about alternative ongoing research using autophagy to increase the clearance of the abnormal protein which causes Huntington's disease.

                              Finally, Professor Barker explains how using these two approaches together could be additive and work synergistically to reduce the protein that is causing the disease and thereby stop the disease process. 

                              Professor Roger Barker, Professor of Clinical Neuroscience, University of Cambridge


                              ​​

                              ​​​11:21 minutes - Professor Roger Barker, Professor of Clinical Neuroscience, University of Cambridge.

                              See our range of Huntingtin products here. 


                              ​Recombinant monoclonal antibodies and proteins for Huntington's disease research

                              Get reproducible, batch-to-batch consistency using recombinant monoclonal antibodies and proteins for your HD research. These are a selection of our best selling products for some of the most important HD targets.​

                              Antibodies

                              Gene nameTarget nameAbIDApplicationsSpecies
                              HTTHuntingtinab109115Flow Cyt, IHC-FoFr, ICC/IF, WB, IHC-PMouse, Rat, Human
                              Grin1NMDAR1ab109182WB, ICC/IFMouse, Rat, Human
                              PDE10APDE10Aab227829WB, IHC-Fr, IPMouse, Rat, Human

                              Proteins

                              Target nameAbIDSpeciesExpression system

                              Huntingtin

                              ab112300HumanWheat germ 

                              NMDAR1

                              ab158584HumanWheat germ
                              PDE10Aab101116HumanBaculovirus




                              Antibody sampler panels

                              Our Huntington's disease antibody sampler panels allow you to try different antibody clones for key Huntington's disease targets to help you pick the right antibody for your research. Each panel contains 20µl aliquots of at least five different antibody clones.​

                              PanelDescriptionAbID
                              Autophagy Marker Antibody Sampler PanelAutophagy Antibody Panel Sampler Panel contains multiple trial-sized versions of clones against APG5L/ATG5, ATG16L1, ATG4B, ATG9A, Beclin 1, and LC3B specifically selected for high performance in various applications.ab228525

                              Autophagy Analysis
                              Antibody Sampler Panel

                              Autophagy Analysis Antibody Sampler Panel contains multiple trial-sized versions of anti-human, mouse and rat antibody clones against ATG16L1, ATG16L1 pS278, SQSTM1, LC3B, Ubiquitin and M6PR, specifically selected for high performance in various applications.ab269811


                              ​

                              Key cell and neuronal markers from Abcam

                              To help you get ahead in your Huntington’s research, we’ve compiled the best neuronal markers to use in conjunction with our disease-specific antibodies.

                              Neural markersMarker groupRecommended product
                              Ki67Proliferating cell markerab16667
                              GFAPSchwann cell/radial glia/astrocyteab33922, ab68428
                              VIMRadial gliaab92547
                              NeuNMature neuronab177487
                              MAP2Mature neuronab183830
                              TUBB3Immature neuronab78078
                              MBPOligodendrocyteab218011
                              PSD95Mature neuronab18258
                              NESRadial gliaab105389
                              DCXImmature neuronab18723
                              SYPMature neuronab32127
                              NOTCH1Astrocyteab52627
                              THDopaminergic neuronab137869
                              S100BAstrocyteab52642
                              MAPTMature neuron/axonsab80579, ab32057, ab109390 (phospho S396)






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