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Radial glia divide asymmetrically to produce one radial glia cell and one intermediate progenitor cell (IPC). IPCs differentiate into post-mitotic immature neurons, which migrate to their final destination in the nervous system and integrate into the neuronal network.
Intermediate progenitors
TBR2
A transcription factor whose expression marks the transition from radial glia to intermediate progenitors.
Embryonic (E15) mouse cortical sections stained with anti-TBR2 (red) (ab23345).
MASH1 (Ascl1)
A transcription factor essential for neural differentiation. Please note that it can also label active neural stem cells.
Mouse subventricular zone tissue sections stained with anti-MASH1 (ab74065).
Immature neurons
Doublecortin
A microtubule-associated phosphoprotein that promotes neurite extension and cell migration.
Mouse adult dentate gyrus sections stained with anti-doublecortin (red) (ab18723).
Beta III tubulin
A class of tubulin whose expression is limited to neurons and is used to label immature neurons.
Mouse embryonic spinal cord stained with anti-beta III tubulin (red) (ab78078).
NeuroD1
A transcription factor that promotes neuronal development.
Mouse brain tissue stained with anti-neuroD1 (ab60704).
TBR1
A transcription factor whose expression marks the transition from intermediate progenitors to post-mitotic neurons.
Mouse brain sections stained with anti-TBR1 (red) (ab31940).
Stathmin 1
A cytoplasmic phosphoprotein involved in cytoskeletal regulation.
Mouse brain tissue sections stained with anti-stathmin 1 (ab109986).