Mature neuron markers
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A quick reference guide to mature neuron markers
Mature neurons are terminally differentiated and are no longer able to divide. Their purpose is to receive, process, and transfer information in the central and peripheral nervous systems.
NeuN
An RNA binding protein that is highly specific for post-mitotic neurons. However, the following cell types do not express NeuN:
- Golgi cells
- Purkinje cells
- Olfactory bulb mitral cells
- Retinal photoreceptor cells
- Inferior olivary and dentate nucleus neurons
- Sympathetic ganglion cells
Mouse cerebrum sections stained with anti-NeuN (green) (ab177487).
Read about the advantages of our NeuN recombinant rabbit monoclonal antibody (ab177487)
MAP2
A neuron-specific protein that promotes assembly and stability of the microtubule network.
Mouse cortex tissue stained with anti-MAP2 (green) (ab183830).
160 kDa Neurofilament medium
Major intermediate filament found in neurons.
Human brain tissue stained using anti-160 kDa neurofilament medium (ab68142).
Neurofilament heavy
Major intermediate filament found in neurons.
Mouse hippocampus tissue stained using anti-neurofilament heavy (green) (ab207176).
Synaptophysin
Synaptic vesicle protein that regulates vesicle endocytosis in neurons.
Human iPS cell-derived neurons stained with anti-synaptophysin (green) (ab32127).
PSD95
Synaptic protein that associates with receptors and the cytoskeleton.
Mouse retina tissue stained with anti-PSD95 (green) (ab238135).
References
- El-Husseini, A. E. et al. PSD-95 involvement in maturation of excitatory synapses. Science 290, 1364–8 (2000).Kwon, S. E. & Chapman, E. R. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron 70, 847–54 (2011).Mullen, R. J., Buck, C. R. & Smith, A. M. NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201–211 (1992).Soltani, M. H. et al. Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. Am. J. Pathol. 166, 1841–1850 (2005).Trojanowski, J. Q., Walkenstein, N. & Lee, V. M. Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies. J. Neurosci. 6, 650–660 (1986).Yuan, a., Rao, M. V., Veeranna & Nixon, R. a. Neurofilaments at a glance. J. Cell Sci. 125, 3257–3263 (2012).El-Husseini, A. E. et al. PSD-95 involvement in maturation of excitatory synapses. Science 290, 1364–8 (2000).
- Kwon, S. E. & Chapman, E. R. Synaptophysin regulates the kinetics of synaptic vesicle endocytosis in central neurons. Neuron 70, 847–54 (2011).
- Mullen, R. J., Buck, C. R. & Smith, A. M. NeuN, a neuronal specific nuclear protein in vertebrates. Development 116, 201–211 (1992).
- Soltani, M. H. et al. Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. Am. J. Pathol. 166, 1841–1850 (2005).
- Trojanowski, J. Q., Walkenstein, N. & Lee, V. M. Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies. J. Neurosci. 6, 650–660 (1986).
- Yuan, a., Rao, M. V., Veeranna & Nixon, R. a. Neurofilaments at a glance. J. Cell Sci. 125, 3257–3263 (2012).