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Microglia markers (미세아교세포)

Related

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            • Overview of microglia subtypes and markers

              Microglia marker (미세아교세포 마커)에 대한 한 눈에 보는 가이드

              Published August 8, 2022 

              ​Microglia는 중추신경계(CNS)에서 면역 방어 역할을 하는 뇌와 척수의 대식세포입니다. Microglia와 대식세포는 계통를 공유하기 때문에 많은 마커가 두 세포 유형 모두에 공통적입니다. 본 가이드는 새로운 microglia 특이 마커인 TMEM119에 특별히 중점을 두고, 흔히 사용되는 microglia 마커를 제시합니다.

              Jump to: TMEM119| CD11b and CD45| Iba1| CX3CR1| F4/80 | CD68 | CD40

              TMEM119

              TMEM119는 세포 표면 단백질이며 마우스와 휴먼 모두에 특이적인 microglia 마커입니다. 다른 microglia 마커와는 달리, 이 마커는 대식세포나 다른 면역 또는 신경세포 유형에 의해 발현되지 않는다는 장점이 있습니다.

              Anti-TMEM119 (녹색) (ab209064)으로 염색한 mouse brain tissue sections (마우스 뇌 조직 절편).​ 

              Browse all TMEM119 antibodies

              TMEM119 antibody 선택하기:

              Required species reactivityRequired application추천 제품
              MouseImmunohistochemistryAnti-TMEM119 antibody [28-3] - Microglial marker (ab209064)
              MouseFlow cytometryAnti-TMEM119 antibody [106-6] - Microglial marker (ab210405)
              HumanImmunohistochemistry

              Anti-TMEM119 antibody - C-terminal (ab185333)

              Corresponding blocking peptide for ab185333: TMEM119 peptide (ab207307)



              CD11b 및 CD45

              CD11b와 CD45 표지의 조합을 사용하여 microglia와 대식세포를 구별할 수 있습니다. Resting microglia(휴지 미세아교세포)는 CD11bhi, CD45low 인 반면, 대식세포는 CD11bhi, CD45hi 입니다.

              추천 제품 Recombinant Anti-CD45 antibody [EPR20033] (ab208022) 

              이미지 (왼쪽): Anti-CD11b antibody (green) (ab133357)로 염색한 mouse tissue (Eo771 breast cancer)

              Browse all CD11b antibodies
              Browse all CD45 antibodies


              ​Iba1

              이온화된 calcium-binding adaptor molecule 1 (Iba1)은 활성화된 microglia에서 막 주름 형성 및 포식 작용에 관여하는 microglia 및 대식세포 특이적 칼슘 결합 단백질입니다.

              추천 제품 Recombinant Anti-Iba1 antibody [EPR16588] (ab178846)

              Anti-Iba1 antibody (녹색)(ab178846)으로 염색한 mouse cerebral cortex tissue sections(마우스 대뇌 피질 조직 절편)

              Browse all Iba1 antibodies
              Browse all Iba1 proteins and peptides


              CX3CR1

              CX3CR1은 fractalkine receptor (프랙토카인 수용체)로, CNS에서 microglia와 대식세포 모두의 표면에서 발견되며, 이 부위에서 신경세포가 분비하는 CX3CL1(fractalkine)에 반응합니다.

              추천 제품 Recombinant Anti-CX3CR1 antibody [EPR22354-15] (ab245248)

              이미지(왼쪽): Rabbit monoclonal IgG (ab172730) isotype control (왼쪽)과 비교한 anti-CX3CR1 antibody(오른쪽) (ab245248)로 염색한 human peripheral blood mononuclear cells의 flow cytometry 분석.

              Browse all CX3CR1 antibodies
              Browse all CX3CR1 proteins and peptides


              ​​F4/80

              F4/80은 대식세포 및 resting microglia 표면에서 발견되는 160 KDa 당단백질(glycoprotein)입니다.

              추천 제품 Recombinant Anti-F4/80 antibody [SP115] (ab111101)

              이미지(왼쪽): Anti-F4/80 [SP115] antibody (ab111101)으로 염색한 mouse liver tissue sections (마우스 간 조직 절편).

              Browse all F4/80 antibodies
              Browse all F4/80 proteins and peptides


              CD68

              CD68은 대식세포 및 활성화된 microglia에 의해 높은 수준으로 발현되고 resting microglia에 의해 낮은 수준으로 발현되는 lysosomal protein입니다.

              추천 제품 Recombinant Anti-CD68 antibody [EPR20545] (ab213363)

              이미지(왼쪽): anti-CD68 antibody (ab213363)로 염색한 human cervical carcinoma tissue sections (휴먼 자궁경부암 조직 절편).

              Browse all CD68 antibodies
              Browse all CD68 proteins and peptides


              CD40

              CD40은 항원 제시(antigen presentation)에 필요한 세포 표면 분자이며 활성화된 microglia 및 대식세포에 의해 발현됩니다.

              추천 제품 Recombinant Anti-CD40 antibody [EPR20735] (ab224639)

              이미지(왼쪽): anti-CD40  antibody (ab224639)로 염색한 human diffuse large B-cell lymphoma tissue sections (광범위B형대세포림프종 조직 절편).

              Browse all CD40 antibodies
              Browse all CD40 ELISA kits
              Browse all CD40 proteins and peptides

              References

              • Bennetta, M. L. et al. New tools for studying microglia in the mouse and human CNS. PNAS 113, 1738-1746 (2016). doi:10.1073/pnas.1525528113
              • Bhasin, M., Wu, M. & Tsirka, S. E. Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis. BMC Immunol. 8, 10 (2007).
              • Becher, B. & Antel, J. P. Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia 18, 1–10 (1996).
              • Ford, A. L., Goodsall, A. L., Hickey, W. F. & Sedgwick, J. D. Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J. Immunol. 154, 4309–21 (1995).
              • Imai, Y., Ibata, I., Ito, D., Ohsawa, K. & Kohsaka, S. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem. Biophys. Res. Commun. 224, 855–62 (1996).
              • Ito, D., Tanaka, K., Suzuki, S., Dembo, T. & Fukuuchi, Y. Enhanced Expression of Iba1, Ionized Calcium-Binding Adapter Molecule 1, After Transient Focal Cerebral Ischemia In Rat Brain. Stroke 32, 1208–1215 (2001).
              • Patel, A. R., Ritzel, R., McCullough, L. D. & Liu, F. Microglia and ischemic stroke: A double-edged sword. International Journal of Physiology, Pathophysiology and Pharmacology 5, 73–90 (2013).
              • Ponomarev, E. D., Shriver, L. P. & Dittel, B. N. CD40 Expression by Microglial Cells Is Required for Their Completion of a Two-Step Activation Process during Central Nervous System Autoimmune Inflammation. J. Immunol. 176, 1402–1410 (2006).
              • Schwabenland, M. et al. Analyzing microglial phenotypes across neuropathologies: a practical guide. Acta Neuropathologica (2021). 


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