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Neural markers (신경세포 마커)

Related

  • Browse directly conjugated neural markers
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                  • Neuroscience resources
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                                Neuron(신경세포)과 glia(아교세포)는 고유한 transcription factors, enzymes, cytoskeletal proteins 및 receptors들을 발현합니다. 사용하기 쉬운 가이드를 통해 최상의 neural subtype marker를 선택하세요.​

                                아래 이미지를 클릭하셔서 Neural marker들을 탐색해 보세요.


                                구글 크롬 또는 인터넷 익스플로러에서 파일 확인이 가능합니다.


                                Download a PDF of our neural markers booklet.


                                Synaptic transmission (시냅스 전달)

                                Synaptic transmission은 신호를 전달하는 neurotransmitter들이 pre-synaptic neuron에 의해 방출되어 이후 post-synaptic neuron의 수용체에 결합해 활성화하는 과정입니다.


                                Synaptic transmission 과정 동안, neurotransmitter들은 시냅스 소포에 축적되고 세포외 배출을 통해 pre-synaptic neuron에서 방출됩니다. Neurotransmitter들은 이어서 시냅스 간격에 걸쳐 확산되어 post-synaptic neuron의 수용체에 결합해 활성화시킵니다.


                                그 후 결합이 post-synaptic neuron의 전기적 변화를 야기합니다. Neurotransmitter는 pre-synaptic neuron에서 방출된 후, 효소에 의한 파괴 또는 pre-synaptic neuron의 재흡수에 의해 빠르게 제거됩니다.


                                Synaptic transmission 시 neurotransmitters 

                                다양한 유형의 neurotransmitter가 존재하는데, 일반적인 유형은 다음과 같습니다.

                                Amino acids:Monamines:Neuropeptides:Others types:
                                GABADopamineSubstance PAcetylcholine
                                GlutamateSerotoninEndorphinsPurines
                                GlycineHistamineEnkephalins-
                                AspartateNorepinephrineSomatostatin-
                                --LHRH-
                                --Opioids-

                                Synaptic transmission에 중요한 역할을 하고 다양한 neurotransmitter들을 생물학적 막을 통과하여 다양한 세포 및 세포 내 위치로 수송하는 데 필수적인 다양한 주요  receptor 및 transporter 들이 있습니다.


                                Neural markers 요약


                                Cell typeMarkers
                                Neuroepithelial cellsNestin, SOX2, Notch1, HES1, HES3, E-cadherin, occludin.
                                Radial gliaVimentin, nestin, PAX6, HES1, HES5, GFAP, GLAST, BLBP, TN-C, N-cadherin, SOX2.
                                Intermediate progenitorsTBR2, MASH1/Ascl1.
                                Immature neuronsDoublecortin, beta III tubulin, NeuroD1, TBR1, stathmin 1.
                                Oligodendrocyte precursor cellsPDGF receptor alpha, NG2.
                                Mature oligodendrocytesOlig 1, olig 2, olig 3, MBP, OSP, MOG, SOX10.
                                Schwann cellsMPZ, NCAM, GAP43, S100, P75NTR.
                                AstrocytesGFAP, EAAT1/GLAST, EAAT2/GLT-1, glutamine synthetase, S100 beta, ALDH1L1.
                                MicrogliaTMEM119, CD11b, CD45, Iba1, CX3CR1, F4/80, CD68, CD40.
                                Mature neuronsNeuN, MAP2, 160 kDa neurofilament medium, 200kDa neurofilament heavy, synaptophysin, PSD95.
                                Glutamatergic neuronsVGLUT1, VGLUT2, NMDAR1, NMDAR2B, glutaminase, glutamine synthetase.
                                GABAergic neuronsGABA transporter 1, GABAB receptors 1 and 2, GAD65, GAD67.
                                Dopaminergic neuronsTyrosine hydroxylase, dopamine transporter, FOXA2, GIRK2, Nurr1, LMX1B
                                Serotonergic neuronsTryptophan hydroxylase, serotonin transporter, Pet1.
                                Cholinergic neuronsCholine acetyltransferase, vesicular acetylcholine transporter, acetylcholinesterase
                                Browse all neuroscience resources
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