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NIRF probes for real-time imaging of amyloid beta

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  • Browse all neurodegeneration resources
    • Conformation-specific Aß antibodies
        • View all Aß products
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                      • Alzheimer's disease interactive pathway

                        Image amyloid beta (Aß) in real-time with near infrared fluorescent (NIRF) probes suitable for both in vitro and in vivo imaging.

                        ​The earliest pathological hallmark of Alzheimer’s disease is the deposition of Aß in the brain. Consequently, the past decade has seen the emergence of imaging probes for the non-invasive detection of Aß, mainly relying on techniques such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). NIRF probes provide a safe, inexpensive, high resolution alternative method for real-time imaging of soluble and insoluble Aß in vivo and in vitro.

                        The advantages of NIRF probes

                        • Ideal for in vivo imaging
                          Emission wavelengths are in the NIR range, minimizing background fluorescence from brain tissue.
                        • Detection of both soluble and insoluble Aß
                          We offer a comprehensive range of probes that allow the detection of both Aß monomers and fibrils (Figure 1).
                        • Cell-permeable
                          All our NIRF probes can cross the blood brain barrier (BBB) allowing labeling of Aß in the brain.
                        • Inexpensive
                          The imaging instrument costs are low, data analysis is quick, and highly skilled personnel are not required.
                        • Safe to use
                          NIRF probes are non-radioactive, eliminating unnecessary exposure to radiation. 


                        Available NIRF probes

                        Product nameλex/λem (nm)Aß species detectedReferences
                        MCAAD-3 (ab216983)596/685Aß42 fibrils1, 3
                        CRANAD-2 (ab141775)640/715Aß40 fibrils1, 4


                        Figure 1.  NIRF probes binding to Aß monomers and fibrils.

                        Browse all amyloid beta NIRF probes



                        References

                        1. Xu, M.-M., Ren, W.-M., Tang, X.-C., Hu, Y.-H. & Zhang, H.-Y. Advances in development of fluorescent probes for detecting amyloid-β aggregates. Nat. Publ. Gr. 37, 719–730 (2016).

                        2. Chongzhao, R. et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-ß deposits. J. Am. Chem. Soc. 131, 15257–15261 (2009).

                        3. Fu, H., Cui, M., Tu, P., Pan, Z. & Liu, B. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes. Chem. Commun. (Camb). 50, 11875–8 (2014).

                        4. Chongzhao, R. et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-ß deposits. J. Am. Chem. Soc. 131, 15257–15261 (2009).

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