For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome
We use cookies to make our site as useful as possible.
Our Cookie Policy explains how you can opt-out of the cookies we use.
If you continue without changing your cookie settings, we'll assume you’re happy with this.
The earliest pathological hallmark of Alzheimer’s disease is the deposition of Aß in the brain. Consequently, the past decade has seen the emergence of imaging probes for the non-invasive detection of Aß, mainly relying on techniques such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). NIRF probes provide a safe, inexpensive, high resolution alternative method for real-time imaging of soluble and insoluble Aß in vivo and in vitro.
Product name | λex/λem (nm) | Aß species detected | References |
MCAAD-3 (ab216983) | 596/685 | Aß42 fibrils | 1, 3 |
CRANAD-2 (ab141775) | 640/715 | Aß40 fibrils | 1, 4 |
Figure 1. NIRF probes binding to Aß monomers and fibrils.
References
1. Xu, M.-M., Ren, W.-M., Tang, X.-C., Hu, Y.-H. & Zhang, H.-Y. Advances in development of fluorescent probes for detecting amyloid-β aggregates. Nat. Publ. Gr. 37, 719–730 (2016).
2. Chongzhao, R. et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-ß deposits. J. Am. Chem. Soc. 131, 15257–15261 (2009).
3. Fu, H., Cui, M., Tu, P., Pan, Z. & Liu, B. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes. Chem. Commun. (Camb). 50, 11875–8 (2014).
4. Chongzhao, R. et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-ß deposits. J. Am. Chem. Soc. 131, 15257–15261 (2009).