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The earliest pathological hallmark of Alzheimer’s disease is the deposition of Aß in the brain. Consequently, the past decade has seen the emergence of imaging probes for the non-invasive detection of Aß, mainly relying on techniques such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). NIRF probes provide a safe, inexpensive, high resolution alternative method for real-time imaging of soluble and insoluble Aß in vivo and in vitro.
|Product name||λex/λem (nm)||Aß species detected||References|
|MCAAD-3 (ab216983)||596/685||Aß42 fibrils||1, 3|
|CRANAD-2 (ab141775)||640/715||Aß40 fibrils||1, 4|
Figure 1. NIRF probes binding to Aß monomers and fibrils.
1. Xu, M.-M., Ren, W.-M., Tang, X.-C., Hu, Y.-H. & Zhang, H.-Y. Advances in development of fluorescent probes for detecting amyloid-β aggregates. Nat. Publ. Gr. 37, 719–730 (2016).
2. Chongzhao, R. et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-ß deposits. J. Am. Chem. Soc. 131, 15257–15261 (2009).
3. Fu, H., Cui, M., Tu, P., Pan, Z. & Liu, B. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes. Chem. Commun. (Camb). 50, 11875–8 (2014).
4. Chongzhao, R. et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-ß deposits. J. Am. Chem. Soc. 131, 15257–15261 (2009).