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The earliest pathological hallmark of Alzheimer’s disease is the deposition of Aß in the brain. Consequently, the past decade has seen the emergence of imaging probes for the non-invasive detection of Aß, mainly relying on techniques such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). NIRF probes provide a safe, inexpensive, high resolution alternative method for real-time imaging of soluble and insoluble Aß in vivo and in vitro.
|Product name||λex/λem (nm)||Aß species detected||References|
|MCAAD-3 (ab216983)||596/685||Aß42 fibrils||1, 3|
|CRANAD-2 (ab141775)||640/715||Aß40 fibrils||1, 4|
Figure 1. NIRF probes binding to Aß monomers and fibrils.
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