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Oligodendrocytes are responsible for the production of myelin, which insulates the axons of the central nervous system. Their function is equivalent to that of Schwann cells in the peripheral nervous system.
Platelet derived growth factor receptor alpha ,or CD140a, is a cell surface tyrosine kinase receptor and a marker of oligodendrocyte precursor cells.
Image (left): Rat E14.5 intervertebral disc tissue stained with anti-PDGFR alpha (ab203491).
NG2 is a membrane chondroitin sulfate proteoglycan expressed by oligodendrocyte precursor cells. It has many alternative names, including chondroitin sulfate proteoglycan 4 (CSPG4) or melanoma-associated chondroitin sulfate proteoglycan (MCSP).
Image (left): Human melanoma tissue stained with anti-NG2 (ab255811).
These are transcription factors necessary for oligodendrocyte development.
Image (left): Rat brain tissue sections stained with anti-olig2 (green) (ab109186).
OPS is a protein found on the surface of oligodendrocytes in the central nervous system.
Image (left): western blot with anti-oligodendrocyte specific protein antibody [EPR12726] (ab175236) at 1/1000 dilution.
MBP is a structural component of myelin expressed exclusively by myelinating glia.
We recommend Anti-Myelin Basic Protein antibody (ab40390).
Recommended MBP phorphorylation inhibitor: Arachidonic acid (ab120916).
Image (left): Rat brain tissue sections stained with anti-myelin basic protein (green) (ab40390).
MOG is a glycoprotein found on the surface of oligodendrocytes.
Image (left): Rat cerebellum tissue stained with anti-myelin oligodendrocyte glycoprotein (green) (ab233549).
SOX10 is a transcription factor that directs neural stem cells towards the glial lineage. It should be used in combination with other markers to identify oligodendrocytes.
Image (left): Rat cerebellum tissue sections stained with anti-SOX10 (green) (ab180862).