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Oligodendrocyte markers (희소돌기아교세포 마커)

Related

  • Neural markers guide
    • Directly conjugated neural markers
      • Secondary antibodies for IHC
        • Your guide to optimizing IHC experiments
          • Related products
            • Mature oligodendrocyte marker antibody sampler panel (ab254026)
              • Sign up for the latest neuroscience resources

                Oligodendrocytes와 oligodendrocyte precursor cells 표지 마커 가이드

                Oligodendrocytes는 중추신경계에서 axon을 절연시키는 myelin의 생성을 담당합니다. 이들의 기능은 말초 신경계의 슈반 세포 (Schwann cells)와 동등합니다.

                Oligodendrocyte precursor cells

                (희소돌기아교세포 전구세포​)

                PDGFR alpha (PDGFRA)

                혈소판 유래 성장인자 수용체 알파(Platelet derived growth factor receptor alpha), 또는 CD140a는 세포 표면 tyrosine kinase receptor 이며 oligodendrocyte precursor cell의 마커입니다.

                추천 제품: Recombinant Anti-PDGFR alpha antibody [EPR22059-270] (ab203491) 

                Image (left): Rat E14.5 intervertebral disc tissue stained with anti-PDGFR alpha (ab203491).

                PDGFR alpha antibodies 전체 리스트 보기


                Neural-glial antigen 2 (NG2)

                NG2는 oligodendrocyte precursor cells에 의해 발현되는 막 콘드로이틴 황산 프로테오글리칸(membrane chondroitin sulfate proteoglycan)입니다. 이는 chondroitin sulfate proteoglycan 4 (CSPG4) 또는 melanoma-associated chondroitin sulfate proteoglycan (MCSP)을 포함한 많은 대체 명칭을 가지고 있습니다. 

                추천 제품: Recombinant Anti-NG2 antibody [EPR22410-145] (ab255811)

                Image (left): Human melanoma tissue stained with anti-NG2 (ab255811).

                NG2 antibodies 전체 리스트 보기

                Mature oligodendrocytes

                Olig 1, 2, and 3

                Olig 1, 2, 3 은 oligodendrocytes 발생에 필요한 전사 인자입니다.

                추천 제품: Recombinant Anti-Olig2 antibody [EPR2673] (ab109186)

                Image (left): Rat brain tissue sections stained with anti-olig2 (green) (ab109186).

                olig 1, 2, and 3 antibodies 전체 리스트 보기

                Discover more


                Oligodendrocyte specific protein (OSP)

                OPS는 중추신경계의 oligodendrocytes 표면에서 발견되는 단백질입니다.

                추천 제품: Recombinant Anti-Oligodendrocyte Specific Protein antibody [EPR12726] (ab175236)

                Image (left): western blot with anti-oligodendrocyte specific protein antibody [EPR12726] (ab175236) at 1/1000 dilution.

                OSP antibodies 전체 리스트 보기


                Myelin basic protein (MBP)

                MBP 는 myelinating glia에서만 발현되는 myelin의 구조적 성분입니다. 

                추천 제품: Anti-Myelin Basic Protein antibody (ab40390)

                추천 MBP phorphorylation inhibitor: Arachidonic acid (ab120916) 

                Image (left): Rat brain tissue sections stained with anti-myelin basic protein (green) (ab40390).

                MBP antibodies 전체 리스트 보기


                ​​Myelin oligodendrocyte glycoprotein (MOG)

                MOG 는 oligodendrocytes 표면에서 발견되는 당단백질입니다. 

                추천 제품: Recombinant Anti-Myelin oligodendrocyte glycoprotein antibody [EPR22629-310] (ab233549). 

                Image (left): Rat cerebellum tissue stained with anti-myelin oligodendrocyte glycoprotein (green) (ab233549).

                MOG antibodies 전체 리스트 보기


                SOX10

                SOX10 는 신경줄기세포를 아교세포 계통(glial lineage)으로 유도하는 전사 인자입니다. Oligodendrocytes를 식별하기 위해서는 SOX10를 다른 마커와 병용해야 합니다.

                추천 제품: Recombinant Anti-SOX10 antibody [EPR4007-104] (ab180862)

                Image (left): Rat cerebellum tissue sections stained with anti-SOX10 (green) (ab180862).

                SOX10 antibodies 전체 리스트 보기

                References

                • Barbarese, E. et al. Expression and localization of myelin basic protein in oligodendrocytes and transfected fibroblasts. J. Neurochem. 51, 1737–45 (1988).
                • Dyer, C. A., Hickey, W. F. & Geisert, E. E. Myelin/oligodendrocyte-specific protein: a novel surface membrane protein that associates with microtubules. J. Neurosci. Res. 28, 607–13 (1991).
                • Marques, S. et al. Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system. Science 352, 1326–9 (2016).
                • Mei, F. et al. Stage-specific deletion of Olig2 conveys opposing functions on differentiation and maturation of oligodendrocytes. J. Neurosci. 33, 8454–62 (2013).
                • Pozniak, C. D. et al. Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression. Proc. Natl. Acad. Sci. U. S. A. 107, 21795–800 (2010).
                • Scolding, N. J. et al. Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation. J. Neuroimmunol. 22, 169–176 (1989).
                • Takeda M, S. B. Arachidonic acid inhibits myelin basic protein phosphorylation in cultured oligodendrocytes.Glia 277–84 (1997).
                • Zhou, Q., Choi, G. & Anderson, D. J. The bHLH transcription factor Olig2 Promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron 31, 791–807 (2001).
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