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Explore Parkinson's disease and access the tools you need to better understand this complex condition.
>> In collaboration with The MJFF, we developed a range of RabMAb® products to bring you the tools you need for Parkinson’s disease research. Please see here to find out more about these products and our partnership.
Parkinson's disease pathway
Explore our interactive Parkinson's disease pathway poster to find the best products for your target of interest.
Professor Roger Barker, Professor of Clinical Neuroscience, University of Cambridge
Professor Barker explains where we are with research in 2019 and how our understanding of the disease has progressed, before exploring emerging trends and therapies.
Emerging trends discussed include the role of alpha-synuclein, drug repurposing, providing ‘fertilizer’ to dopamine cells such as in GDNF trials, stem cell-derived dopamine replacement, and gene therapy.
15:55 minutes - Professor Roger Barker, Professor of Clinical Neuroscience, University of Cambridge.
Recombinant monoclonal antibodies for Parkinson's disease research
Get reproducible, batch-to-batch consistency using recombinant monoclonal antibodies for your PD research. These are some of our best selling products.
|LRRK2||ab133474||ICC/IF, IHC-FrFl, IHC-P, IP, WB||Hu, Ms, Rt|
|ab138501||ELISA, Flow Cytometry, ICC/IF, IHC-P, IP, WB||Hu, Drosophila melanogaster|
|DJ-1 (PARK7)||WB, IP, IHC-P, Flow Cyt, ICC/IF||Hu, Ms, Rt|
|Rab8A||ab237702||WB, IP||Mo, Rt, Hu|
|Rab10||ab237703||IP, Flow Cytometry, ICC/IF, WB||Mo, Rt, Hu|
|Rab12 (phospho S106)||ab256487||Dot blot, WB||Mo, Hu|
RAB29 (phospho T71)
|ab241062||Dot Blot, WB||Hu|
|Parkin||ab77924||IHC-Fr, Flow Cytometry, WB, IP||Mo, Rt, Hu, Drosophila melanogaster|
|ab216144||WB, ICC/IF, IP||Hu|
Cerebrovasular pathology in Parkinson's disease
Learn how cerebrovascular lesions may contribute to changing connectivity within the brain and result in more severe PD from Professor Angelo Antonini, Professor of Neurology at the Department of Neurosciences, University of Padova.
Here Prof. Antonini explains how people with vascular lesions in the brain differ in clinical manifestations and response to traditional PD medications from those without lesions. He also talks us through imaging tracers available for studying cerebrovascular pathology.
Markers for mixed pathology in Parkinson's disease
We've compiled a list of markers to help you studying mixed pathology in Parkinson's disease.
|SNAP25||SNAP25||ab109105||WB, IP, Flow Cyt, ICC/IF||Mouse, Rat, Human||Involved in the molecular regulation of neurotransmitter release and synaptic function|
|PSD95||DLG4||ab76115||WB, IP, IHC (PFA fixed)||Mouse, Rat, Human||Required for synaptic plasticity associated with NMDA receptor signaling|
IP, Flow Cyt, IHC-P, ICC/IF, WB
|Mouse, Human||Signaling protein involved in vasculogenesis|
|MAPT||Tau||ab32057||IHC-P, IHC-Fr, WB, IP||Mouse, Rat, Human||Stabilizes neuronal microtubules, and is the main constituent of neurofibrillary tangles|
|APP||Amyloid 1-42||ab201060||IHC-FrFl, WB, Dot blot, IHC-P, IHC-FoFr||Mouse, Human||Beta-amyloid peptide involved in some neurodegenerative pathologies|
Antibody panels and kits for Parkinson's disease research
Our Parkinson’s disease panels contain antibodies against several targets in 10 μL sampler vials to give you access to antibodies in a convenient and cost-effective format.
LRRK2 Antibody Sampler Panel (ab263464)
Alpha-Synuclein Antibody Sampler Panel (ab263465)
Rab Family (RAB4, RAB5, RAB7, RAB8A, RAB9, RAB10) Antibody Sampler Panel (ab263466)
Microglia Marker Antibody Sampler Panel (ab226482)
Neuroinflammation Marker Antibody Sampler Panel - Human (ab263462)
Mature Neuron Marker Antibody Sampler Panel (ab218257)
Autophagy Marker Antibody Sampler Panel (ab228525)
Our ELISA kits allow for sensitive and reliable results and are suitable for a wide range of samples, including plasma, cerebrospinal fluid, and tissue extract. Our SimpleStep ELISA® kits can have results within 90-minutes.
Human Parkin ELISA Kit (ab212159)
Human IL-1a ELISA Kit (ab178008)
Human TNF alpha ELISA Kit (ab181421)
Cellular ROS/RNS Assay Kit (ab139473)
TUNEL Assay Kit - FITC (ab66108)
Human Alpha-synuclein ELISA Kit (ab210973)
Human PARK7 ELISA Kit (ab215535)
Human Tau ELISA Kit (ab210972)
Human RAB8 ELISA Kit (ab255718)
RAB10 ELISA Kit (ab255717)
To help you get ahead in your Parkinson’s disease research, we’ve compiled the best markers to use in conjunction with our disease-specific antibodies.
|Gene name||Target name||AbID||Applications||Species|
|MFN2||Mitofusin-2||ab124773||ICC/IF, IHC-P, WB||Mouse, Rat, Human|
|UCHL1||PGP9.5||ab108986||ICC/IF, IHC-Fr, WB, IP, IHC-P, Flow Cyt||Mouse, Rat, Human|
|TH||Tyrosine hydroxylase||ab75875||Flow Cyt, ICC/IF, IHC-P, WB||Mouse, Rat, Human, Pig|
|TOMM20||TOMM20||ab186734||Flow Cyt, ICC/IF, IHC-P, WB||Mouse, Rat, Human|
|CTSD||Cathepsin D||ab75852||Flow Cyt, ICC/IF, WB, IP, IHC-P||Mouse, Human|
|CTSB||Cathepsin B||ab214428||Flow Cyt, IHC-P, WB, ICC/IF||Mouse, Rat|
Other key cell and neuronal markers from Abcam
Check out our range of neuronal markers for supporting your research.
Proliferating cell marker
Schwann cell/radial glia/astrocyte
Alpha-synuclein proteins are major components of Lewy bodies, intraneuronal aggregates characteristic for Parkinson's disease. Using alpha-synuclein protein aggregates and monomers will allow you to induce Lewy body pathology in both in vivo and in vitro experiments. You can explore the Lewy body pathology with our recombinant human alpha-synuclein proteins, developed in collaboration with The MJFF.
|Recombinant human alpha-synuclein protein filament||SDS-PAGE, functional studies, dot blot||Human||ab254309|
|Recombinant human alpha-synuclein monomer||Mass spectrometry, SDS-PAGE, HPLC||Human||ab254310|