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During neurogenesis, neuroepithelial (NE) cells transform into radial glia. Epithelial features such as tight junctions are downregulated in favor of adherens junctions. Glial hallmarks begin to emerge, including astrocyte markers and morphological features such as glycogen granules.
Vimentin is an intermediate filament protein, whose expression is upregulated during the epithelial to mesenchymal transition of NE cells to radial glia and persists until astrocyte development.
Recommended vimentin inhibitor and antiangiogenic agent: Withaferin A (ab120644)
Image (left): Rhesus monkey brain tissue sections stained with anti-vimentin (ab92547).
These astrocytic markers emerge as neuroepithelial cells become radial glia.
We recommend Anti-BLBP antibody (ab32423).
Recommended downregulator of GFAP expression: Methylprednisolone (ab142007)
Image (left): Rat embryonic (E16) spinal cord sections stained with anti-BLBP (ab32423).
Upregulation of adhesion and extracellular matrix proteins accompanies the transformation of NE cells into radial glia.
Image (left): Mouse embryonic coronal cortical section stained with anti-N -cadherin (red) (ab76011).
Nestin is an intermediate filament protein in NE cells and radial glia, whose expression persists until astrocyte development.
Image (left): Rat adult brain tissue sections stained with anti-nestin (ab6142).
SOX2 is a transcription factor and the earliest marker of the neural plate. It is expressed in proliferating cells and those that acquire glial fates, but downregulated in post-mitotic neurons.
We recommend Anti-SOX2 antibody (ab97959).
Image (left): Chicken embryonic (E7) brain tissue sections stained with anti-SOX2 (ab97959).