Serotonergic neuron markers

Commonly used serotonergic neuron markers

Serotonergic neurons synthesize the neurotransmitter serotonin (5-HT), which is found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS).

Tryptophan hydroxylase (TPH)

An enzyme involved in serotonin synthesis. There are two isoforms of tryptophan hydroxylase, TPH1 and TPH2. TPH2 is the isoform predominantly found in the brain.​

Mouse dorsal raphe coronal brain slices stained with anti-TPH2 (ab111828).

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Serotonin transporter (SERT)
A transmembrane protein responsible for the re-uptake of 5-HT from the synaptic cleft into the presynaptic neuron.​

Human cerebral cortex stained with anti-serotonin transporter (ab174770).

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​Serotonin transporter inhibitors

ProductActivity
Desvenlafaxine (ab145741)
Potent SERT and NET inhibitor
Potent SERT and norepinephrine transporter (NET) inhibitor
Nisoxetine hydrochloride (ab141134)Potent SERT and NET inhibitor
Duloxetine (ab143249)Dual NET/SERT inhibitor
Venlafaxine hydrochloride (ab120715)Selective NET/SERT i



Pet1
A transcription factor that drives the transcription of genes essential for the metabolism as well as re-uptake of serotonin.

Human fetal brain lysate stained using anti-pet1 (ab182111).

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References

  • Deecher, D. C. et al. Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor. J. Pharmacol. Exp. Ther. 318, (2006).
  • Hendricks, T. J. et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37, 233–247 (2003).
  • Kittler, K., Lau, T. & Schloss, P. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons. Eur. J. Pharmacol. 629, 63–67 (2010).
  • Liu, C. et al. Pet-1 is required across different stages of life to regulate serotonergic function. Nat. Neurosci. 13, 1190–1198 (2010).
  • Zhou, J. Norepinephrine transporter inhibitors and their therapeutic potential. Drugs Future 29, 1235–1244 (2004).



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