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Serotonergic neurons synthesize the neurotransmitter serotonin (5-HT), which is found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS).
Tryptophan hydroxylase (TPH)
An enzyme involved in serotonin synthesis. There are two isoforms of tryptophan hydroxylase, TPH1 and TPH2. TPH2 is the isoform predominantly found in the brain.
Mouse dorsal raphe coronal brain slices stained with anti-TPH2 (ab111828).
Serotonin transporter (SERT)
A transmembrane protein responsible for the re-uptake of 5-HT from the synaptic cleft into the presynaptic neuron.
Human cerebral cortex stained with anti-serotonin transporter (ab174770).
Serotonin transporter inhibitors
|Nisoxetine hydrochloride (ab141134)||Potent SERT and NET inhibitor|
|Duloxetine (ab143249)||Dual NET/SERT inhibitor|
|Venlafaxine hydrochloride (ab120715)||Selective NET/SERT i|