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Traumatic brain injury

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                            Explore traumatic brain injury (TBI) and access the tools you need to support your research. 

                            ​​​​

                            ​​Contents 

                            • What is traumatic brain injury?
                            • Importance of biomarkers in TBI
                            • Professor Kaj Blennow on the role of biomarkers in TBI and acute neuronal injury research
                            • Biomarkers in TBI - interactive poster
                            • Recombinant monoclonal antibodies and proteins for TBI research
                            • ELISA kits for TBI research
                            • References

                            What is traumatic brain injury?​​

                            TBI pathogenesis is a complex process that affects millions of individuals around the world. TBI typically originates from an initial injury, related directly to an external impact to the brain, and followed by the gradual development of secondary pathogenesis. The secondary pathogenesis consists of a molecular, chemical, and inflammatory cascade, involving the release of excitatory neurotransmitters, and results in either temporary or permanent neurological deficits.1

                            ​Importance of biomarkers in TBI

                            The complex pathophysiology of TBI hinders the development of rapid biofluid-based diagnostic tests for the management of patients with TBI, including those in the intensive care unit or emergency room. Axonal injury is the most common type of brain injury due to the extended length of axonal fiber tracts. However, TBI-induced damage may affect neuronal bodies, dendrites, and synapses as well as other types of neural cells such as astroglial cells and oligodendrocytes. Therefore, a panel of neuronal injury biomarkers may be a potential solution to access the multi-component pathology of brain injury.2

                            Biomarkers in traumatic brain injury and acute neuronal damage

                            Learn more about the role of biomarkers in TBI and acute neuronal injury research from Professor Kaj Blennow, chief physician at the Institute of Neuroscience and Physiology, University of Gothenburg. Prof. Blennow talks us through promising biomarkers (GFAP, UCHL1, S100B, NFL) that can identify neuronal damage and predict outcomes after the concussion. He further focuses on neurofilament light (NFL) biomarker and highlights that the NFL can potentially serve as a blood biomarker for acute neuronal damage.

                            ​​​Blood biomarkers for TBI and acute neuronal injury may have several clinical applications: to diagnose neuronal injuries after concussions in sports and to predict outcomes after TBI or cardiac arrest, accompanied by hypoxic brain injury.

                            ​

                            ​​Biomarkers in traumatic brain injury- interactive poster

                            ​​​Explore our interactive poster on biomarkers in TBI and find the best products for your target of interest. 

                            ​

                            ​

                            Recombinant monoclonal antibodies and proteins for TBI research​

                            Get reproducible, batch-to-batch consistency using recombinant monoclonal antibodies and proteins for your TBI research. These are some of our best-selling products. 

                            Antibodies 

                            Gene nameTarget name Location of injuryRecommended abID
                            UCHL1PGP9.5Neuronal cell body2ab108986
                            GFAPGFAPAstroglia2ab68428
                            S100BS100BAstroglia2ab52642
                            NEFLNFLAxon2ab223343
                            MAPTMAPTAxon2ab92676
                            MBPMBPMyelin2ab209328
                            ENO2NSENeuronal cell body2ab220216
                            BDNFBDNFSynapse3ab108319
                            DLG4PSD95Synapse4ab76115


                            Proteins

                            Product nameSpeciesExpression systemabID

                            Recombinant human PGP9.5 protein (Active)

                            HumanEscherichia coli

                            ab269110

                            Recombinant Human GFAP protein

                            HumanWheat germ 

                            ab114149

                            Recombinant Human S100 beta protein

                            HumanEscherichia coliab222425

                            Recombinant Human 68kDa Neurofilament/NF-L protein (His tag)

                            HumanEscherichia coliab224840

                            Recombinant Human Myelin Basic Protein (Tagged)

                            HumanEscherichia coliab43614

                            Recombinant Human NSE protein

                            HumanEscherichia coliab78797

                            Recombinant human BDNF protein

                            HumanEscherichia coli

                            ab206642

                            Recombinant Human PSD95 protein

                            HumanWheat germab131874
                            ​​

                            Our Neuroinflammation Marker (BDNF, ICAM1, TREM2, GFAP, TNF alpha, Iba1) Antibody Panel - Human (ab263462) combines recombinant monoclonal antibodies against several neuroinflammation targets in 10 μL sampler vials, providing you access to antibodies in a convenient and cost-effective format. ​

                            ELISA kits for TBI research

                            Our ELISA kits are sensitive, reliable and suitable for a wide range of samples, including plasma, cerebrospinal fluid, and tissue extract. Our SimpleStep ELISA® kits allow you to achieve results within 90-minutes.

                            • Human BDNF ELISA Kit (ab212166)
                            • S100B ELISA Kit (ab234573)
                            • Mouse UCHL1 ELISA Kit (ab235641)
                            • Human GFAP ELISA Kit (ab223867)
                            • Human Tau ELISA kit (ab210972)
                            • Human NSE ELISA kit (ab217778)
                            • Human H-FABP ELISA kit (ab243682)
                            • Human IL-10 ELISA kit (ab185986)

                            Check out our FirePlex Human Key Cytokines - Immunoassay Panel (ab243549), which contains recombinant monoclonal antibodies against key human cytokines and allows you to run a 17-plex assay.

                            References

                            1. Galgano, M., et al. Traumatic brain injury: current treatment strategies and future endeavors. Cell Transplant. 26, 1118–1130 (2017).
                            2. Wang, K.K., Yang, Z., Zhu, T., et al. An update on diagnostic and prognostic biomarkers for traumatic brain injury. Expert Rev Mol Diagn.18,165–180 (2018).
                            3. Song, M., Martinowich, K., Lee, F.S. BDNF at the synapse: why location matters. Mol Psychiatry. 22, 1370–1375 (2017).
                            4. Keith, D. & El-Husseini, A. Excitation control: balancing PSD-95 function at the synapse. Front. Mol. Neurosci. 1: 4 (2008).





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