Overview

  • Product name

  • Description

    Rabbit polyclonal to Neuroserpin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rhesus monkey
  • Immunogen

    Recombinant fragment within Human Neuroserpin (internal sequence). The exact sequence is proprietary.
    Database link: Q99574

  • Positive control

    • WB: Mouse brain lysate; HEK-293T and MOLT-4 whole cell lysates. IHC-P: Mouse forebrain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab228864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 46 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
  • Tissue specificity

    Predominantly expressed in the brain.
  • Involvement in disease

    Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
  • Sequence similarities

    Belongs to the serpin family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp781N13156 antibody
    • Neuroserpin antibody
    • NEUS_HUMAN antibody
    • Peptidase inhibitor 12 antibody
    • PI-12 antibody
    • PI12 antibody
    • Protease inhibitor 12 antibody
    • Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1 antibody
    • Serine or cysteine proteinase inhibitor clade I member 1 antibody
    • Serpin I1 antibody
    • Serpin peptidase inhibitor clade I (neuroserpin) member 1 antibody
    • SERPINI1 antibody
    see all

Images

  • Anti-Neuroserpin antibody (ab228864) at 1/500 dilution + Mouse brain lysate at 50 µg

    Predicted band size: 46 kDa



    10% SDS-PAGE gel.

  • All lanes : Anti-Neuroserpin antibody (ab228864) at 1/1000 dilution

    Lane 1 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
    Lane 2 : MOLT-4 (human lymphoblastic leukemia cell line) whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 46 kDa



    10% SDS-PAGE gel.

  • Paraffin-embedded mouse forebrain tissue stained for Neuroserpin using ab228864 at 1/500 dilution in immunohistochemical analysis.

References

ab228864 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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